Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.34 |
| ▸ | GRN | P28799 | 2/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.33 |
| ▸ | SHMT1 | P34896 | 2/20 | 0.32 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.32 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.32 |
| ▸ | ACE | P12821 | 3/20 | 0.32 |
| ▸ | BCHE | P06276 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.30 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.30 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7424356 | 0.93 | HDAC1 (0.36) | HDAC1HDAC6GRNSORT1SHMT1 | |
| SCHEMBL7423323 | 0.88 | BCHE (0.33) | HDAC1HDAC6BCHEMEN1KMT2A | |
| SCHEMBL7426438 | 0.84 | L3MBTL1 (0.34) | HDAC1HDAC6GRNSORT1MAPT | |
| SCHEMBL7426906 | 0.81 | HDAC1 (0.37) | HDAC1HDAC6BCHEMEN1KMT2A | |
| SCHEMBL7419020 | 0.81 | GRN (0.38) | GRNSORT1ACE2ACE | |
| SCHEMBL7425812 | 0.80 | GRN (0.33) | GRNSORT1ACE2ACE | |
| SCHEMBL7422281 | 0.80 | SHMT1 (0.39) | GRNSORT1SHMT1SHMT2MAPT | |
| SCHEMBL7421104 | 0.80 | GRN (0.32) | GRNSORT1ACE2ACE | |
| SCHEMBL7430634 | 0.78 | AOC3 (0.39) | GRNSORT1 | |
| SCHEMBL7426730 | 0.77 | AOC3 (0.43) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |