Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | ASF1A | Q9Y294 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7423535 | 0.87 | SMN1; SMN2 (0.44) | SMN1; SMN2NPC1RAB9ALMNAHTT | |
| SCHEMBL7426644 | 0.86 | GRN (0.50) | SMN1; SMN2ALDH1A1NR1H4MEN1KMT2A | |
| SCHEMBL7378949 | 0.85 | MME (0.50) | ALDH1A1LMNAGAA | |
| SCHEMBL7426474 | 0.84 | GRIA2 (0.52) | SMN1; SMN2NPC1RAB9AALDH1A1LMNA | |
| SCHEMBL7427045 | 0.84 | GRIA2 (0.52) | SMN1; SMN2NPC1RAB9AALDH1A1LMNA | |
| SCHEMBL7425053 | 0.84 | CA2 (0.50) | ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL7539973 | 0.81 | GRIA4 (0.54) | SMN1; SMN2NPC1RAB9AALDH1A1LMNA | |
| SCHEMBL7428501 | 0.80 | L3MBTL1 (0.46) | SMN1; SMN2NPC1RAB9AALDH1A1LMNA | |
| SCHEMBL7417901 | 0.79 | FOLH1 (0.57) | ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL7423140 | 0.79 | CTSS (0.48) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |