Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | GRN | P28799 | 2/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | FABP1 | P07148 | 1/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7426644 | 0.88 | GRN (0.50) | SMN1; SMN2GRNSORT1CA2KMT2A | |
| SCHEMBL7425540 | 0.87 | DGAT1 (0.47) | SMN1; SMN2LMNANPC1RAB9AHTT | |
| SCHEMBL7427045 | 0.81 | GRIA2 (0.52) | SMN1; SMN2LMNANPC1RAB9AGRN | |
| SCHEMBL7426474 | 0.81 | GRIA2 (0.52) | SMN1; SMN2LMNANPC1RAB9AGRN | |
| SCHEMBL7425053 | 0.81 | CA2 (0.50) | LMNAGRNSORT1CA2KMT2A | |
| SCHEMBL7423341 | 0.79 | ALDH1A1 (0.47) | HTTGAA | |
| SCHEMBL7424801 | 0.78 | CTSS (0.46) | SMN1; SMN2MAPK1 | |
| SCHEMBL8255226 | 0.77 | LMNA (0.52) | SMN1; SMN2LMNANPC1RAB9ATHRB | |
| SCHEMBL5869961 | 0.77 | LMNA (0.52) | SMN1; SMN2LMNANPC1RAB9ATHRB | |
| SCHEMBL7417901 | 0.77 | FOLH1 (0.57) | LMNAGRNSORT1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |