Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 2/20 | 0.52 |
| ▸ | FPR2 | P25090 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | GRN | P28799 | 2/20 | 0.39 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427045 | 1.00 | GRIA2 (0.52) | GRIA2FPR2NPC1RAB9AGRN | |
| SCHEMBL7420632 | 0.85 | ALDH1A1 (0.41) | GRIA2NPC1RAB9AGRNSORT1 | |
| SCHEMBL7425540 | 0.84 | DGAT1 (0.47) | GRIA2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL7423535 | 0.81 | SMN1; SMN2 (0.44) | NPC1RAB9AGRNSORT1MEN1 | |
| SCHEMBL7421300 | 0.81 | RAB9A (0.40) | NPC1RAB9AGRNSORT1MEN1 | |
| SCHEMBL7426644 | 0.80 | GRN (0.50) | GRNSORT1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7429170 | 0.80 | ALDH1A1 (0.46) | FPR2ALDH1A1MAPTCTSL | |
| SCHEMBL7425607 | 0.79 | CTSL (0.48) | CTSL | |
| SCHEMBL7428501 | 0.78 | L3MBTL1 (0.46) | FPR2NPC1RAB9AGRNSORT1 | |
| SCHEMBL5869763 | 0.78 | FOLH1 (0.48) | GRIA2FPR2NPC1RAB9AGRN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |