Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.51 |
| ▸ | TLR4 | O00206 | 2/20 | 0.45 |
| ▸ | TLR2 | O60603 | 2/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | EPOR | P19235 | 2/20 | 0.43 |
| ▸ | CETP | P11597 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10873829 | 0.86 | LTA4H (0.59) | LTA4HTLR4TLR2LMNAMAPT | |
| SCHEMBL11397964 | 0.86 | TLR4 (0.50) | LTA4HTLR4TLR2ALOX5PTGS1 | |
| SCHEMBL29161712 | 0.82 | MAOB (0.44) | LTA4HTLR4TLR2ALOX5PTGS1 | |
| SCHEMBL29254135 | 0.80 | ALOX5 (0.48) | LTA4HTLR4TLR2ALOX5PTGS1 | |
| SCHEMBL160454 | 0.80 | LMNA (0.43) | LTA4HPTGS2LMNA | |
| SCHEMBL28049061 | 0.79 | MAOA (0.51) | LTA4HTLR4TLR2ALOX5PTGS1 | |
| SCHEMBL11442885 | 0.78 | MAPT (0.50) | LTA4HTLR4TLR2ALOX5PTGS1 | |
| SCHEMBL11304733 | 0.78 | MAPT (0.50) | LTA4HTLR4TLR2ALOX5PTGS1 | |
| SCHEMBL27693342 | 0.77 | EPOR (0.50) | LTA4HTLR4TLR2ALOX5PTGS1 | |
| SCHEMBL4141490 | 0.77 | CHRM5 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212306-A2 | HYDROXYALKANOYLAMINOLACTAMS AND RELATED STRUCTURES AS INHIBITORS OF ABETA PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001019797-A2 | HYDROXYALKANOYL AMINOLACTAMS AND RELATED STRUCTURES AS INHIBITORS OF Aβ PROTEIN PRODUCTION | DU PONT PHARMACEUTICALS COMPANY (US) | 2001-03-22 | — | — | WO | disclosed |