Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.41 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.41 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.41 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091440 | 0.95 | ABCB1 (0.52) | SIGMAR1ABCB1TDP1L3MBTL1CALM1 | |
| SCHEMBL6570928 | 0.82 | HTR2A (0.42) | SIGMAR1 | |
| SCHEMBL10422126 | 0.79 | HTR1A (0.43) | ABCB1TDP1ALDH1A1 | |
| SCHEMBL5632470 | 0.79 | LTA4H (0.69) | SIGMAR1ABCB1TDP1L3MBTL1CALM1 | |
| SCHEMBL5332631 | 0.79 | KCNH2 (0.40) | SIGMAR1ALDH1A1 | |
| SCHEMBL7672336 | 0.77 | TUBB4A (0.50) | SIGMAR1ABCB1CALM1LTA4HALDH1A1 | |
| SCHEMBL2661090 | 0.76 | KCNH2 (0.38) | SIGMAR1ABCB1ALDH1A1MEN1KMT2A | |
| SCHEMBL8078997 | 0.76 | SIGMAR1 (0.49) | SIGMAR1TDP1L3MBTL1CALM1LTA4H | |
| SCHEMBL2355634 | 0.75 | LTA4H (0.75) | SIGMAR1ABCB1TDP1L3MBTL1LTA4H | |
| SCHEMBL140371 | 0.75 | ADRA1A (0.40) | L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1127049-A1 | BRIDGED HETEROCYCLIC DERIVATIVES | GPI NIL Holdings, Inc. (US) | 2001-08-29 | — | — | EP | disclosed |
| WO-2000016603-A2 | BRIDGED HETEROCYCLIC DERIVATIVES | GPI NIL HOLDINGS, INC. (US) | 2000-03-30 | — | — | WO | disclosed |