Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.40 |
| ▸ | PYGL | P06737 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7420944 | 0.84 | PYGL (0.49) | PYGLALDH1A1KDM4E | |
| SCHEMBL7425491 | 0.72 | KDM4E (0.36) | PYGLALDH1A1KDM4EADRA1A | |
| SCHEMBL7415758 | 0.69 | ACE (0.36) | PYGLKDM4E | |
| SCHEMBL8889889 | 0.69 | ALDH1A1 (0.35) | PYGLALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL8891676 | 0.67 | ALDH1A1 (0.37) | ALDH1A1MEN1KMT2ATSHRKDM4E | |
| SCHEMBL8890894 | 0.66 | ALDH1A1 (0.36) | PYGLALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL7427520 | 0.64 | PYGL (0.49) | PYGLALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL8891397 | 0.63 | SCN9A (0.45) | MAPK1ALDH1A1HTR1ATSHRLMNA | |
| SCHEMBL434910 | 0.62 | AADAT (0.55) | AADATHTR1AMAPTDRD2 | |
| SCHEMBL8890217 | 0.61 | GLA (0.36) | ALDH1A1MEN1KMT2ATSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5594006-A | SUCH AS COLLEGENASE, STROMELYSIN; ANTICANCER AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-14 | — | — | US | disclosed |
| EP-0641323-A1 | CARBOSTYRIL DERIVATIVES AS MATRIX METALLOPROTEINASES INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-03-08 | — | — | EP | disclosed |
| WO-1994021612-A1 | CARBOSTYRIL DERIVATIVES AS MATRIX METALLOPROTEINASES INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-09-29 | — | — | WO | disclosed |