Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.44 |
| ▸ | CTSS | P25774 | 3/20 | 0.44 |
| ▸ | REN | P00797 | 5/20 | 0.40 |
| ▸ | METAP2 | P50579 | 4/20 | 0.39 |
| ▸ | METAP1 | P53582 | 2/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7424569 | 0.77 | CTSL (0.46) | CTSKCTSSRENCTSLCTSB | |
| SCHEMBL7301464 | 0.77 | METAP2 (0.40) | CTSKCTSSRENMETAP2METAP1 | |
| SCHEMBL27709473 | 0.77 | CTSK (0.48) | CTSKCTSSRENMETAP2AAK1 | |
| SCHEMBL7327399 | 0.76 | CTSK (0.48) | CTSKCTSSRENMETAP2METAP1 | |
| SCHEMBL7264708 | 0.75 | CTSK (0.54) | CTSKCTSSAAK1HDAC4HDAC1 | |
| SCHEMBL8233824 | 0.75 | CTSK (0.54) | CTSKCTSSAAK1HDAC4HDAC1 | |
| SCHEMBL7294534 | 0.74 | CTSL (0.47) | CTSKCTSSRENMETAP2METAP1 | |
| SCHEMBL8242631 | 0.73 | CTSS (0.52) | CTSKCTSSRENMETAP2AAK1 | |
| SCHEMBL10346884 | 0.73 | REN (0.39) | CTSKCTSSRENMETAP2METAP1 | |
| SCHEMBL7337095 | 0.72 | CTSK (0.47) | CTSKCTSSRENMETAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0371179-A1 | Novel analogs of peptidase substrates | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-06-06 | — | — | EP | disclosed |
| EP-0368719-A2 | Novel analogs of peptidase substrates | MERRELL PHARMACEUTICALS INC. (US) | 1990-05-16 | — | — | EP | disclosed |