Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 3/20 | 0.43 |
| ▸ | ATP4B | P51164 | 3/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437724 | 0.85 | ATP4A (0.61) | ATP4AATP4BMAPTALDH1A1LMNA | |
| SCHEMBL7438579 | 0.84 | MAPT (0.51) | ALOX5MAPTALDH1A1LMNAHTT | |
| SCHEMBL7441165 | 0.81 | CYP3A4 (0.44) | ATP4AATP4BALOX5MAPTALDH1A1 | |
| SCHEMBL7434501 | 0.81 | ALOX5 (0.50) | ALOX5MAPTMEN1KMT2AGAA | |
| SCHEMBL7441627 | 0.78 | ALDH1A1 (0.61) | ATP4AATP4BALOX5MAPTALDH1A1 | |
| SCHEMBL7440079 | 0.77 | PKM (0.47) | ATP4AATP4BALDH1A1 | |
| SCHEMBL7436155 | 0.76 | MAPT (0.42) | ALOX5MAPTALDH1A1HTTMEN1 | |
| SCHEMBL7444066 | 0.76 | MAPT (0.42) | ALOX5MAPTALDH1A1HTTMEN1 | |
| SCHEMBL7430796 | 0.76 | LTA4H (0.57) | ATP4AATP4BALOX5MAPTALDH1A1 | |
| SCHEMBL7433535 | 0.75 | MAPT (0.57) | ALOX5MAPTALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506194-B1 | 4-aryl-thiazole or imidazole derivatives | AKZO NOBEL NV (NL) | 1996-08-21 | — | — | EP | disclosed |
| US-5462959-A | 4-aryl-imidazole derivatives | AKZO N.V. (NL) | 1995-10-31 | — | — | US | disclosed |
| US-5254575-A | 4-aryl-thiazole derivatives | AKZO N.V. (NL) | 1993-10-19 | — | — | US | disclosed |
| EP-0506194-A1 | 4-aryl-thiazole or imidazole derivatives | Akzo Nobel N.V. (NL) | 1992-09-30 | — | — | EP | disclosed |