Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ATP4A | P20648 | 2/20 | 0.41 |
| ▸ | ATP4B | P51164 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6664214 | 0.84 | ATP4A (0.60) | CYP3A4CYP2D6CYP2C9SCN9ARAB9A | |
| SCHEMBL2734989 | 0.83 | RAB9A (0.54) | CYP3A4RAB9ASMN1; SMN2ALOX5ABL1 | |
| SCHEMBL7429957 | 0.81 | ATP4A (0.43) | RAB9ASMN1; SMN2ATP4AATP4BALOX5 | |
| SCHEMBL7440680 | 0.80 | ABL1 (0.57) | RAB9AALOX5ABL1MEN1KMT2A | |
| SCHEMBL16238595 | 0.76 | CYP3A4 (0.50) | CYP3A4CYP2D6CYP2C9SCN9ARAB9A | |
| SCHEMBL168593 | 0.76 | ALDH1A1 (0.56) | CYP3A4CYP2D6CYP2C9SCN9ARAB9A | |
| SCHEMBL3088513 | 0.76 | MAP2K3 (0.50) | CYP3A4CYP2D6CYP2C9SCN9ARAB9A | |
| SCHEMBL5999257 | 0.75 | KDM4E (0.55) | RAB9ASMN1; SMN2CDC7DBF4MEN1 | |
| SCHEMBL7436623 | 0.75 | PKM (0.55) | CYP3A4CYP2D6CYP2C9SCN9ARAB9A | |
| SCHEMBL7438064 | 0.75 | MAPT (0.43) | CYP3A4CYP2D6CYP2C9SCN9AMAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506194-B1 | 4-aryl-thiazole or imidazole derivatives | AKZO NOBEL NV (NL) | 1996-08-21 | — | — | EP | disclosed |
| US-5462959-A | 4-aryl-imidazole derivatives | AKZO N.V. (NL) | 1995-10-31 | — | — | US | disclosed |
| US-5254575-A | 4-aryl-thiazole derivatives | AKZO N.V. (NL) | 1993-10-19 | — | — | US | disclosed |
| EP-0506194-A1 | 4-aryl-thiazole or imidazole derivatives | Akzo Nobel N.V. (NL) | 1992-09-30 | — | — | EP | disclosed |