Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.45 |
| ▸ | METAP1 | P53582 | 3/20 | 0.45 |
| ▸ | MC4R | P32245 | 1/20 | 0.45 |
| ▸ | MC3R | P41968 | 1/20 | 0.45 |
| ▸ | DPEP1 | P16444 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.40 |
| ▸ | REN | P00797 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | CPA1 | P15085 | 2/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 2/20 | 0.38 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7430623 | 1.00 | METAP2 (0.45) | METAP2METAP1MC4RMC3RDPEP1 | |
| SCHEMBL8894607 | 0.89 | MME (0.43) | METAP2METAP1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL8894601 | 0.89 | MME (0.43) | METAP2METAP1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL7444348 | 0.88 | DPEP1 (0.44) | METAP2METAP1DPEP1SLC1A3SLC1A2 | |
| SCHEMBL7444337 | 0.88 | DPEP1 (0.44) | METAP2METAP1DPEP1SLC1A3SLC1A2 | |
| SCHEMBL7436178 | 0.85 | EPHX1 (0.42) | METAP2METAP1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL7433904 | 0.85 | LDHA (0.45) | METAP2METAP1POLBRENPPARG | |
| SCHEMBL7436183 | 0.85 | EPHX1 (0.42) | METAP2METAP1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL7433911 | 0.85 | LDHA (0.45) | METAP2METAP1POLBRENPPARG | |
| SCHEMBL7434192 | 0.82 | SLC1A3 (0.50) | SLC1A3SLC1A2SLC1A1CPA1MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643878-A | TREATMENT OF RETROVIRAL DISEASES LIKE AIDS | CIBA-GEIGY CORPORATION (US) | 1997-07-01 | — | — | US | disclosed |
| EP-0618222-A2 | Dipeptid derivatives of 5-amino-4-hydroxy-hexanoic acid | CIBA-GEIGY AG (CH) | 1994-10-05 | — | — | EP | disclosed |
| EP-0532466-A2 | Derivatives of 5-amino-4-hydroxy-hexanoic acid and their therapeutical use | CIBA-GEIGY AG (CH) | 1993-03-17 | — | — | EP | disclosed |