Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.45 |
| ▸ | METAP2 | P50579 | 3/20 | 0.45 |
| ▸ | METAP1 | P53582 | 2/20 | 0.45 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | FAP | Q12884 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433911 | 1.00 | LDHA (0.45) | LDHAMETAP2METAP1CPB2EPHX2 | |
| Hydrochloric Acid SCHEMBL9876367 | 0.88 | MMP1 (0.47) | METAP2METAP1CPB2EPHX2REN | |
| SCHEMBL8894601 | 0.86 | MME (0.43) | METAP2METAP1PPARGRENANPEP | |
| SCHEMBL8894607 | 0.86 | MME (0.43) | METAP2METAP1PPARGRENANPEP | |
| SCHEMBL7430623 | 0.85 | METAP2 (0.45) | METAP2METAP1PPARGDPP4FAP | |
| SCHEMBL7430616 | 0.85 | METAP2 (0.45) | METAP2METAP1PPARGDPP4FAP | |
| SCHEMBL8891774 | 0.84 | LDHA (0.56) | LDHAPPARGKMT2ACYP1A2CYP2D6 | |
| SCHEMBL8891766 | 0.84 | LDHA (0.56) | LDHAPPARGKMT2ACYP1A2CYP2D6 | |
| SCHEMBL7436178 | 0.83 | EPHX1 (0.42) | METAP2METAP1PPARGDPP4FAP | |
| SCHEMBL7444348 | 0.83 | DPEP1 (0.44) | METAP2METAP1EPHX2PPARGDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643878-A | TREATMENT OF RETROVIRAL DISEASES LIKE AIDS | CIBA-GEIGY CORPORATION (US) | 1997-07-01 | — | — | US | disclosed |
| EP-0618222-A2 | Dipeptid derivatives of 5-amino-4-hydroxy-hexanoic acid | CIBA-GEIGY AG (CH) | 1994-10-05 | — | — | EP | disclosed |
| EP-0532466-A2 | Derivatives of 5-amino-4-hydroxy-hexanoic acid and their therapeutical use | CIBA-GEIGY AG (CH) | 1993-03-17 | — | — | EP | disclosed |