Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434800 | 0.85 | SLC9A1 (0.41) | ALDH1A1SLC9A1PTGS2PTGS1NPC1 | |
| SCHEMBL7426997 | 0.84 | MAPT (0.36) | ALDH1A1SLC9A1MAPTLMNA | |
| SCHEMBL7440169 | 0.81 | SLC9A1 (0.41) | ALDH1A1SLC9A1PTGS2MAPTPKM | |
| SCHEMBL7432382 | 0.79 | LMNA (0.39) | ALPLCA9ALDH1A1PTGS2NPC1 | |
| SCHEMBL7432591 | 0.77 | ALDH1A1 (0.37) | ALPLCA9ALDH1A1PTGS2PTGS1 | |
| SCHEMBL7434507 | 0.76 | ALPL (0.47) | ALPLCA9ALDH1A1NPC1MAPT | |
| SCHEMBL7440585 | 0.72 | ALPL (0.37) | ALPLCA9ALDH1A1PTGS2PTGS1 | |
| SCHEMBL7432377 | 0.66 | ALPL (0.38) | ALPLCA9ALDH1A1PTGS2NPC1 | |
| SCHEMBL7438866 | 0.62 | SCN9A (0.41) | ALDH1A1SLC9A1PTGS2PTGS1NPC1 | |
| SCHEMBL11049642 | 0.62 | ALPL (0.42) | ALPLCA9ALDH1A1PTGS2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506194-B1 | 4-aryl-thiazole or imidazole derivatives | AKZO NOBEL NV (NL) | 1996-08-21 | — | — | EP | disclosed |
| US-5462959-A | 4-aryl-imidazole derivatives | AKZO N.V. (NL) | 1995-10-31 | — | — | US | disclosed |
| US-5254575-A | 4-aryl-thiazole derivatives | AKZO N.V. (NL) | 1993-10-19 | — | — | US | disclosed |
| EP-0506194-A1 | 4-aryl-thiazole or imidazole derivatives | Akzo Nobel N.V. (NL) | 1992-09-30 | — | — | EP | disclosed |