Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7428297 | 0.90 | HTR1A (0.53) | HTR1AHRH3SLC6A4SLC7A5 | |
| SCHEMBL7435077 | 0.88 | LTA4H (0.47) | HTR1AHRH3SLC6A4LTA4HKDM4E | |
| SCHEMBL7427779 | 0.82 | SLC7A5 (0.61) | HTR1AHRH3SLC6A4LTA4HSLC7A5 | |
| SCHEMBL7436479 | 0.81 | LTA4H (0.44) | HTR1ALTA4HALDH1A1 | |
| SCHEMBL7437461 | 0.79 | HTR1A (0.62) | HTR1AHRH3SLC6A4LTA4HKDM4E | |
| SCHEMBL7440734 | 0.77 | HTR1A (0.49) | HTR1AHRH3SLC6A4KDM4ESLC7A5 | |
| SCHEMBL7435335 | 0.76 | HTR1A (0.68) | HTR1AHRH3SLC6A4LTA4H | |
| SCHEMBL7444415 | 0.76 | HRH3 (0.49) | HTR1AHRH3SLC6A4LTA4HKDM4E | |
| SCHEMBL7434240 | 0.76 | SLC6A4 (0.61) | HTR1AHRH3SLC6A4LTA4H | |
| SCHEMBL7435344 | 0.76 | HTR1A (0.55) | HTR1AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0571685-A1 | Aryloxyheteroarylpropylamines, their preparation and use | NOVO NORDISK A/S (DK) | 1993-12-01 | — | — | EP | claimed |
| EP-0571685-A1 | Aryloxyheteroarylpropylamines, their preparation and use | NOVO NORDISK A/S (DK) | 1993-12-01 | — | — | EP | disclosed |