Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7446269 | 0.81 | HPGD (0.32) | HPGD | |
| SCHEMBL7436269 | 0.81 | MAPT (0.43) | HPGDPOLBMAPTNPC1RAB9A | |
| SCHEMBL7434182 | 0.77 | TAS1R3 (0.31) | MAPTSMN1; SMN2TAS1R3TAS1R1 | |
| SCHEMBL7426673 | 0.76 | HPGD (0.48) | HPGDMAPTRAB9AALDH1A1KMT2A | |
| SCHEMBL7427958 | 0.75 | TSHR (0.47) | HPGDMAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL7440246 | 0.75 | HPGD (0.44) | HPGDPOLBALDH1A1KDM4EKMT2A | |
| SCHEMBL7434827 | 0.73 | HPGD (0.45) | HPGDMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10996527 | 0.71 | BAX (0.30) | — | |
| SCHEMBL7437345 | 0.70 | RAB9A (0.50) | HPGDPOLBMAPTNPC1RAB9A | |
| SCHEMBL7436499 | 0.70 | GNAI3 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4558129-A | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade | SYNTEX (U.S.A.) INC. (US) | 1985-12-10 | — | — | US | disclosed |
| US-4499100-A | CARDIOUVASCULAR DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1985-02-12 | — | — | US | disclosed |