Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 3/20 | 0.39 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7440239 | 0.81 | PNMT (0.39) | HPGDPOLBLMNACYP2C9THRB | |
| SCHEMBL7437881 | 0.80 | ALDH1A1 (0.49) | POLBTP53GLALMNAL3MBTL1 | |
| SCHEMBL7426673 | 0.80 | HPGD (0.48) | HPGDTHRBALDH1A1MEN1KMT2A | |
| SCHEMBL7435505 | 0.78 | PNMT (0.36) | HPGDPOLBLMNATHRBPNMT | |
| SCHEMBL7427958 | 0.76 | TSHR (0.47) | HPGDTHRBKDM4EMEN1KMT2A | |
| SCHEMBL7446273 | 0.75 | HPGD (0.44) | HPGDPOLBGLAALDH1A1KDM4E | |
| SCHEMBL7434827 | 0.74 | HPGD (0.45) | HPGDTP53THRBALDH1A1KDM4E | |
| SCHEMBL10989168 | 0.72 | THRB (0.36) | POLBTHRBPNMT | |
| SCHEMBL7437345 | 0.71 | RAB9A (0.50) | HPGDPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL7435716 | 0.71 | PNMT (0.33) | HPGDPOLBTHRBPNMTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4558129-A | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade | SYNTEX (U.S.A.) INC. (US) | 1985-12-10 | — | — | US | disclosed |
| US-4499100-A | CARDIOUVASCULAR DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1985-02-12 | — | — | US | disclosed |