Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 3/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.38 |
| ▸ | METTL3 | Q86U44 | 3/20 | 0.37 |
| ▸ | METTL14 | Q9HCE5 | 3/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | VCP | P55072 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8110562 | 0.87 | RAB9A (0.40) | SIGMAR1METTL3METTL14VCPMAPT | |
| SCHEMBL8102814 | 0.85 | VCP (0.50) | SIGMAR1VCP | |
| SCHEMBL7400198 | 0.82 | CHRM1 (0.34) | CHRM1SLC6A2SLC6A4SIGMAR1VCP | |
| SCHEMBL7448002 | 0.80 | HRH3 (0.48) | DRD4DRD3VCP | |
| SCHEMBL8102563 | 0.79 | MTNR1A (0.41) | CHRM1SLC6A2SLC6A4SIGMAR1VCP | |
| SCHEMBL8112708 | 0.75 | MTNR1A (0.40) | SIGMAR1VCPALOX15 | |
| SCHEMBL8111909 | 0.74 | ALDH1A1 (0.35) | SIGMAR1VCPMAPT | |
| SCHEMBL7453786 | 0.70 | GAA (0.56) | DRD4SIGMAR1DRD3DRD5ALOX15 | |
| SCHEMBL7296680 | 0.68 | HRH3 (0.52) | DRD4DRD3VCP | |
| SCHEMBL7303201 | 0.67 | CXCR6 (0.55) | VCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711299-B1 | AZABICYCLOALKYL DERIVATIVES OF IMIDAZO(1,5-a)INDOL-3-ONE AS 5HT 3 ANTAGONISTS | PHARMACIA & UPJOHN SPA (IT) | 2000-01-05 | — | — | EP | disclosed |
| US-5637596-A | REACTING AMINOMETHYLINDOLE DERIVATIVE WITH A CARBONYL CONTAINING CYCLIZING AGENT; 5-HT3 RECEPTOR ATAGONIST; USEFUL FOR TREATING ANXIETY, PSYCHOSIS, GUT MOTILITY DISORDER, EMESIS, MIGRAINE AND DRUG ADDICTION | PHARMACIA S.P.A. (IT) | 1997-06-10 | — | — | US | disclosed |