Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | VCP | P55072 | 1/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.37 |
| ▸ | HTR3B | O95264 | 2/20 | 0.37 |
| ▸ | HTR3A | P46098 | 2/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8112708 | 0.88 | MTNR1A (0.40) | MTNR1AMTNR1BVCPHTR3EHTR3B | |
| SCHEMBL7400198 | 0.85 | CHRM1 (0.34) | VCPAVPR1AHTR3EHTR3BHTR3A | |
| SCHEMBL8102814 | 0.81 | VCP (0.50) | VCPHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8111998 | 0.79 | CHRM1 (0.39) | VCPSIGMAR1CHRM1SLC6A2SLC6A4 | |
| SCHEMBL8111909 | 0.78 | ALDH1A1 (0.35) | VCPHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7448002 | 0.76 | HRH3 (0.48) | VCPCHRNA7HRH4 | |
| SCHEMBL8110562 | 0.75 | RAB9A (0.40) | VCPHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7448878 | 0.70 | GAA (0.56) | HTR3ACHRNA7SIGMAR1 | |
| SCHEMBL8396136 | 0.69 | HTR3E (0.51) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL13585385 | 0.68 | CARM1 (0.56) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711299-B1 | AZABICYCLOALKYL DERIVATIVES OF IMIDAZO(1,5-a)INDOL-3-ONE AS 5HT 3 ANTAGONISTS | PHARMACIA & UPJOHN SPA (IT) | 2000-01-05 | — | — | EP | disclosed |
| US-5637596-A | REACTING AMINOMETHYLINDOLE DERIVATIVE WITH A CARBONYL CONTAINING CYCLIZING AGENT; 5-HT3 RECEPTOR ATAGONIST; USEFUL FOR TREATING ANXIETY, PSYCHOSIS, GUT MOTILITY DISORDER, EMESIS, MIGRAINE AND DRUG ADDICTION | PHARMACIA S.P.A. (IT) | 1997-06-10 | — | — | US | disclosed |