Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 known ✓ | P30556 | 4/20 | 0.54 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.54 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.54 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7048382 | 0.96 | AGTR1 (0.58) | AGTR1ABCC3ABCC2AGTR2 | |
| SCHEMBL9593121 | 0.89 | AGTR1 (0.52) | AGTR1ABCC3ABCC2AGTR2 | |
| SCHEMBL6967063 | 0.84 | AGTR1 (0.47) | AGTR1ABCC3ABCC2 | |
| SCHEMBL6968424 | 0.81 | AGTR1 (0.58) | AGTR1 | |
| SCHEMBL6959552 | 0.81 | AGTR1 (0.43) | AGTR1ABCC3ABCC2 | |
| SCHEMBL8314073 | 0.78 | AGTR1 (0.44) | AGTR1 | |
| SCHEMBL9593779 | 0.77 | KDM4E (0.45) | AGTR1AGTR2 | |
| SCHEMBL4943548 | 0.77 | AGTR1 (0.58) | AGTR1ABCC3ABCC2AGTR2 | |
| Eprosartan SCHEMBL5785067 | 0.75 | AGTR1 (0.92) | AGTR1ABCC3ABCC2 | |
| Eprosartan SCHEMBL41396 | 0.75 | AGTR1 (0.92) | AGTR1ABCC3ABCC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0565634-B1 | ANGIOTENSIN II RECEPTOR BLOCKING COMPOSITIONS | SMITHKLINE BEECHAM CORP (US) | 1999-03-17 | — | — | EP | claimed |
| US-5656650-A | TREATING HYPERTENSION | SMITHKLINE BEECHAM CORP. | 1997-08-12 | — | — | US | claimed |
| EP-0565634-A1 | ANGIOTENSIN II RECEPTOR BLOCKING COMPOSITIONS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-10-20 | — | — | EP | claimed |
| WO-1992010097-A1 | ANGIOTENSIN II RECEPTOR BLOCKING COMPOSITIONS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-06-25 | — | — | WO | claimed |