Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 9/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7461978 | 0.81 | MAOA (0.44) | GRM2MAOA | |
| SCHEMBL8892282 | 0.80 | NAMPT (0.41) | ADORA2A | |
| SCHEMBL7465489 | 0.74 | MEN1 (0.42) | ALDH1A1 | |
| SCHEMBL8891141 | 0.72 | ITGB3 (0.40) | GRM2ALDH1A1 | |
| SCHEMBL28023734 | 0.72 | FADS1 (0.60) | GRM2 | |
| SCHEMBL7461829 | 0.71 | ITGB3 (0.45) | MAOA | |
| SCHEMBL5762328 | 0.71 | GRM2 (0.53) | GRM2MAOA | |
| SCHEMBL7457894 | 0.70 | MAOA (0.36) | GRM2MAOA | |
| SCHEMBL7462123 | 0.70 | ADORA2A (0.48) | ADORA2A | |
| SCHEMBL8893573 | 0.70 | ADORA2A (0.48) | GRM2PTPN1ADORA2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0697408-B1 | 1 substituted-phenyl-oxazolidene-2-one derivatives and their use as adhesion-receptor antagonists | MERCK PATENT GMBH (DE) | 2002-01-23 | — | — | EP | disclosed |
| US-5614535-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-03-25 | — | — | US | disclosed |
| EP-0697408-A1 | 1 substituted-phenyl-oxazolidene-2-one derivatives and their use as adhesion-receptor antagonists | MERCK PATENT GmbH (DE) | 1996-02-21 | — | — | EP | disclosed |