Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 10/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | ADK | P55263 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7471383 | 0.89 | ACHE (0.47) | ACHEGSK3BSIRT2SIRT1HTT | |
| SCHEMBL7471975 | 0.78 | HTT (0.47) | HTTALDH1A1MAPTMAPK1CASP1 | |
| SCHEMBL7474357 | 0.76 | CASP1 (0.53) | ACHESIRT2SIRT1HTTALDH1A1 | |
| SCHEMBL7465749 | 0.75 | GSK3B (0.48) | GSK3BADKALDH1A1MAPTMAPK1 | |
| SCHEMBL7472634 | 0.74 | ALDH1A1 (0.46) | SIRT2SIRT1HTTALDH1A1MAPK1 | |
| SCHEMBL7468750 | 0.73 | CASP3 (0.44) | SIRT2SIRT1HTTALDH1A1MAPT | |
| SCHEMBL7470312 | 0.73 | ALDH1A1 (0.48) | SIRT2SIRT1HTTALDH1A1MAPK1 | |
| SCHEMBL7477205 | 0.73 | KMT2A (0.67) | GSK3BADKHTTALDH1A1MAPT | |
| SCHEMBL7473595 | 0.72 | SIRT2 (0.50) | GSK3BSIRT2SIRT1HTTALDH1A1 | |
| SCHEMBL7472270 | 0.71 | ALDH1A1 (0.55) | SIRT2SIRT1HTTALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869949-B1 | BENZOXAZINE ANTIMICROBIAL AGENTS | ORTHO MCNEIL PHARM INC (US) | 2002-12-18 | — | — | EP | disclosed |
| US-5854242-A | Benzoxazine antimicrobial agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1998-12-29 | — | — | US | disclosed |
| EP-0869949-A1 | BENZOXAZINE ANTIMICROBIAL AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1998-10-14 | — | — | EP | disclosed |
| US-5696117-A | BACTERICIDE | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-12-09 | — | — | US | disclosed |
| WO-1997017333-A1 | BENZOXAZINE ANTIMICROBIAL AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-05-15 | — | — | WO | disclosed |