Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | VNN1 | O95497 | 2/20 | 0.43 |
| ▸ | BRAF | P15056 | 2/20 | 0.43 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.42 |
| ▸ | GRM5 | P41594 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7478759 | 0.86 | MMP2 (0.43) | NAMPTS1PR3ALDH1A1 | |
| SCHEMBL7482004 | 0.83 | ALDH1A1 (0.46) | ALDH1A1 | |
| SCHEMBL7472363 | 0.82 | L3MBTL1 (0.49) | ALDH1A1 | |
| SCHEMBL7476927 | 0.81 | HDAC8 (0.55) | KAT6AALDH1A1 | |
| SCHEMBL7471334 | 0.81 | SMN1; SMN2 (0.52) | KAT6AALDH1A1 | |
| SCHEMBL7482260 | 0.81 | KCNA3 (0.48) | NAMPTBRAFGRM5ALDH1A1RXFP1 | |
| SCHEMBL7472887 | 0.81 | ALDH1A1 (0.48) | ALDH1A1 | |
| SCHEMBL7480996 | 0.81 | RAB9A (0.56) | KAT6AALDH1A1 | |
| SCHEMBL7475904 | 0.79 | MEN1 (0.47) | ALDH1A1 | |
| SCHEMBL7483118 | 0.78 | NR1H4 (0.44) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6472396-B1 | Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-29 | — | — | US | claimed |
| EP-0869947-B1 | BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-23 | — | — | EP | disclosed |