Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.36 |
| ▸ | PARG | Q86W56 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472835 | 0.91 | SMN1; SMN2 (0.43) | HDAC6HDAC1HDAC8SMN1; SMN2HPGD | |
| SCHEMBL7467191 | 0.87 | L3MBTL1 (0.45) | SMN1; SMN2MAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL7466686 | 0.85 | CYP3A4 (0.38) | HDAC6HDAC1HDAC8SMN1; SMN2HPGD | |
| SCHEMBL7468517 | 0.84 | HDAC6 (0.52) | HDAC6HDAC1HDAC8SMN1; SMN2MAPT | |
| SCHEMBL7467186 | 0.81 | NOD1 (0.36) | HDAC6HDAC1HDAC8HPGDMAPT | |
| SCHEMBL7467945 | 0.80 | AKR1B1 (0.39) | HDAC6HDAC1HDAC8SMN1; SMN2HPGD | |
| SCHEMBL7472590 | 0.79 | HDAC6 (0.54) | HDAC6HDAC1HDAC8SMN1; SMN2HPGD | |
| SCHEMBL7461329 | 0.79 | CMA1 (0.46) | HDAC6HDAC1HDAC8SMN1; SMN2HPGD | |
| SCHEMBL7460713 | 0.78 | MAPK8 (0.55) | HDAC6HDAC1HDAC8SMN1; SMN2HPGD | |
| SCHEMBL7464054 | 0.78 | CMA1 (0.48) | SMN1; SMN2HPGDMAPTKDM4ECMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-5814631-A | CHYMASE INHIBITOR, CARDIVASCULAR | SUNTORY LIMITED (JP) | 1998-09-29 | — | — | US | disclosed |
| EP-0795548-A1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |