Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7465842 | 0.82 | DRD4 (0.46) | DRD2DRD4DRD3MEN1KMT2A | |
| SCHEMBL13898533 | 0.82 | LMNA (0.48) | EPHX2ALDH1A1MEN1GLAKMT2A | |
| SCHEMBL7474955 | 0.81 | ALDH1A1 (0.66) | MMP3DRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL13898271 | 0.79 | EPHX2 (0.43) | EPHX2DRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL6161142 | 0.77 | SIGMAR1 (0.58) | MMP3ALDH1A1KMT2AHRH3LMNA | |
| SCHEMBL7477194 | 0.76 | DRD4 (0.59) | MMP3DRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL14747464 | 0.76 | KDM1A (0.46) | EPHX2SMN1; SMN2 | |
| SCHEMBL7468358 | 0.76 | MMP3 (0.46) | MMP3ALDH1A1MEN1GLAKMT2A | |
| SCHEMBL2776191 | 0.76 | SMN1; SMN2 (0.55) | EPHX2SMN1; SMN2 | |
| SCHEMBL2776196 | 0.76 | SMN1; SMN2 (0.55) | EPHX2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757986-B1 | Arylpiperidine and arylpiperazine derivatives and drugs containing the same | SUNTORY LTD (JP) | 2002-06-12 | — | — | EP | disclosed |
| US-5723475-A | Arylpiperidine and arylpiperazine derivatives and medicament containing the same | SUNTORY LIMITED (JP) | 1998-03-03 | — | — | US | disclosed |
| EP-0757986-A1 | ARYLPIPERIDINE AND ARYLPIPERAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SUNTORY LIMITED (JP) | 1997-02-12 | — | — | EP | disclosed |