Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | GRK5 | P34947 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23911866 | 0.80 | NOTUM (0.40) | NOTUMSMN1; SMN2LMNAALDH1A1GAA | |
| SCHEMBL11557905 | 0.79 | MAOA (0.35) | — | |
| SCHEMBL11561229 | 0.79 | FABP6 (0.38) | SMN1; SMN2NPSR1MEN1KMT2ACYP19A1 | |
| SCHEMBL11565003 | 0.79 | NOS3 (0.36) | NOTUMLMNAGAAMAPT | |
| SCHEMBL11561840 | 0.79 | TSHR (0.39) | SMN1; SMN2ALDH1A1GAANPSR1HTT | |
| SCHEMBL29908423 | 0.77 | NR3C2 (0.39) | LMNAALDH1A1LTA4H | |
| SCHEMBL11560280 | 0.76 | KMT2A (0.42) | LMNAALDH1A1GAAMEN1KMT2A | |
| SCHEMBL11564273 | 0.75 | DAO (0.38) | SMN1; SMN2LMNAALDH1A1GAANPSR1 | |
| SCHEMBL11563044 | 0.72 | CYP1A2 (0.46) | SMN1; SMN2ALDH1A1GAANPSR1HPGD | |
| SCHEMBL11562161 | 0.72 | RIPK1 (0.40) | SMN1; SMN2ALDH1A1GAANPSR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711296-B1 | IMIDAZOLYLALKYL DERIVATIVES OF IMIDAZOL[5,1-c][1,4]BENZOXAZIN-1-ONE AND THEIR USE AS THERAPEUTIC AGENTS | PHARMACIA & UPJOHN SPA (IT) | 2000-07-05 | — | — | EP | disclosed |
| EP-0711296-A1 | IMIDAZOLYLALKYL DERIVATIVES OF IMIDAZOL(5,1-c)(1,4)BENZOXAZIN-1-ONE AND THEIR USE AS THERAPEUTIC AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995032208-A1 | IMIDAZOLYLALKYL DERIVATIVES OF IMIDAZOL(5,1-c)(1,4)BENZOXAZIN-1-ONE AND THEIR USE AS THERAPEUTIC AGENTS | PHARMACIA S.P.A. (IT) | 1995-11-30 | — | — | WO | disclosed |
| US-4134974-A | Imidazo[5,1-c][1,4]benzoxazin-1-one | CARLO ERBA S. P. A. (IT) | 1979-01-16 | — | — | US | disclosed |