Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | GALR2 | O43603 | 1/20 | 0.60 |
| ▸ | MITF | O75030 | 1/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | XBP1 | P17861 | 1/20 | 0.60 |
| ▸ | CCR6 | P51684 | 1/20 | 0.60 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6492987 | 0.89 | LMNA (0.53) | LMNASMN1; SMN2NPSR1ALDH1A1POLB | |
| SCHEMBL13088438 | 0.87 | SMN1; SMN2 (0.64) | LMNASMN1; SMN2NPSR1ALDH1A1POLB | |
| SCHEMBL7375343 | 0.86 | SLC9A1 (0.61) | LMNASMN1; SMN2NPSR1ALDH1A1POLB | |
| SCHEMBL32659719 | 0.84 | PDGFRB (0.51) | LMNAALDH1A1POLBHPGDSLC9A1 | |
| SCHEMBL8611539 | 0.84 | SLC9A1 (0.64) | LMNASMN1; SMN2NPSR1ALDH1A1POLB | |
| SCHEMBL14854666 | 0.83 | ALDH1A1 (0.60) | LMNASMN1; SMN2NPSR1ALDH1A1POLB | |
| SCHEMBL26631746 | 0.83 | NPSR1 (0.60) | LMNASMN1; SMN2NPSR1ALDH1A1POLB | |
| SCHEMBL8954112 | 0.82 | SMN1; SMN2 (0.58) | LMNASMN1; SMN2NPSR1ALDH1A1POLB | |
| SCHEMBL6354726 | 0.82 | SLC9A1 (0.59) | LMNASMN1; SMN2NPSR1ALDH1A1POLB | |
| SCHEMBL1786813 | 0.82 | MEN1 (0.51) | LMNAALDH1A1POLBHPGDSLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920319-A4 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO INC (US) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001070227-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 2001-09-27 | — | — | WO | disclosed |
| US-6162813-A | Antagonists of gonadotropin releasing hormone | MERCK & CO., INC. (US) | 2000-12-19 | — | — | US | disclosed |
| US-6150522-A | Antagonists of gonadotropin releasing hormone | MERCK & CO., INC. (US) | 2000-11-21 | — | — | US | disclosed |
| US-6150352-A | ARYLQUINOLONE ANALOGS | MERCK & CO., INC. (US) | 2000-11-21 | — | — | US | disclosed |
| US-6147088-A | USEFUL FOR THE TREATMENT OF A VARIETY OF SEX-HORMONE RELATED CONDITIONS | MERCK & CO., INC. (US) | 2000-11-14 | — | — | US | disclosed |
| EP-0901471-A4 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO INC (US) | 1999-08-25 | — | — | EP | disclosed |
| EP-0918522-A4 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO INC (US) | 1999-08-18 | — | — | EP | disclosed |
| EP-0920319-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | Merck & Co., Inc. (US) | 1999-06-09 | — | — | EP | disclosed |
| EP-0918522-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | Merck & Co., Inc. (US) | 1999-06-02 | — | — | EP | disclosed |
| EP-0901471-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | Merck & Co., Inc. (US) | 1999-03-17 | — | — | EP | disclosed |
| EP-0901489-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | Merck & Co., Inc. (US) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997044339-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1997-11-27 | — | — | WO | disclosed |
| WO-1997044041-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1997-11-27 | — | — | WO | disclosed |
| WO-1997044037-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1997-11-27 | — | — | WO | disclosed |
| WO-1997044321-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1997-11-27 | — | — | WO | disclosed |