Sugi Predict

Sugi Predict / Compounds / SCHEMBL1786813

SCHEMBL1786813

SCHEMBL1786813

COC(=O)c1cc([N+](=O)[O-])c(Cl)cc1Cl

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 2/20 0.51
▸ KMT2A Q03164 2/20 0.51
▸ TDP1 Q9NUW8 1/20 0.50
▸ PDGFRB P09619 1/20 0.50
▸ FGFR1 P11362 1/20 0.50
▸ PDGFRA P16234 1/20 0.50
▸ FLT1 P17948 1/20 0.50
▸ FGFR3 P22607 1/20 0.50
▸ KDR P35968 1/20 0.50
▸ KDM4E B2RXH2 1/20 0.49
▸ LMNA P02545 4/20 0.46
▸ ALDH1A1 P00352 3/20 0.44
▸ MAPT P10636 2/20 0.44
▸ RAF1 P04049 1/20 0.44
▸ HPGD P15428 1/20 0.44
▸ MAPK1 P28482 1/20 0.44
▸ GFER P55789 1/20 0.44
▸ PAX8 Q06710 1/20 0.44
▸ SIRT6 Q8N6T7 1/20 0.44
▸ POLB P06746 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32659719 0.92 PDGFRB (0.51) MEN1KMT2ATDP1PDGFRBFGFR1
SCHEMBL2903296 0.90 TDP1 (0.53) MEN1KMT2ATDP1PDGFRBFGFR1
SCHEMBL1786384 0.87 TDP1 (0.51) MEN1KMT2ATDP1PDGFRBFGFR1
SCHEMBL2243797 0.87 PDGFRB (0.62) MEN1KMT2ATDP1PDGFRBFGFR1
SCHEMBL1788077 0.87 PDGFRB (0.55) MEN1KMT2ATDP1PDGFRBFGFR1
SCHEMBL13680345 0.87 TDP1 (0.53) MEN1KMT2ATDP1PDGFRBFGFR1
SCHEMBL3336950 0.86 TDP1 (0.47) MEN1KMT2ATDP1PDGFRBFGFR1
SCHEMBL7474642 0.86 ALDH1A1 (0.55) MEN1KMT2ATDP1PDGFRBFGFR1
SCHEMBL6745891 0.86 GAA (0.55) MEN1KMT2ATDP1PDGFRBFGFR1
SCHEMBL1787152 0.86 LMNA (0.52) MEN1KMT2ATDP1PDGFRBFGFR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117486818-A N-phenyl thiotriazinone derivative and preparation method and application thereof 贵州大学 2024-02-02 — — CN disclosed
US-11634390-B2 Agricultural chemicals GLOBACHEM NV (BE) 2023-04-25 — — US disclosed
US-11634390-B2 Agricultural chemicals GLOBACHEM NV (BE) 2023-04-25 — — US disclosed
WO-2020117877-A1 COMPOUNDS, COMPOSITIONS AND METHODS OF USE AQUINNAH PHARMACEUTICALS, INC. (US) 2020-06-11 — — WO disclosed
WO-2020117877-A1 COMPOUNDS, COMPOSITIONS AND METHODS OF USE AQUINNAH PHARMACEUTICALS, INC. (US) 2020-06-11 — — WO disclosed
US-20190322627-A1 AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2019-10-24 — — US disclosed
US-20190322627-A1 AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2019-10-24 — — US disclosed
WO-2018122559-A1 AGRICULTURAL CHEMICALS REDAG CROP PROTECTION LTD (GB) 2018-07-05 — — WO disclosed
WO-2018122559-A1 AGRICULTURAL CHEMICALS REDAG CROP PROTECTION LTD (GB) 2018-07-05 — — WO disclosed
US-9340492-B2 Meta-Diarylaniline or meta-diarylpyridinamine compound, preparation method and medical uses thereof INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) 2016-05-17 — — US disclosed
US-20150218088-A1 META-DIARYLANILINE OR META-DIARYLPYRIDINAMINE COMPOUND, PREPARATION METHOD AND MEDICAL USES THEREOF INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) 2015-08-06 — — US disclosed
US-20130203730-A1 BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS ASTRAZENECA AB (SE) 2013-08-08 — — US disclosed
EP-2607357-A1 BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS Astrazeneca AB (SE) 2013-06-26 — — EP disclosed
US-20120115845-A1 THERAPEUTIC AGENTS ALLEN JACK MCQUEEN (GB) 2012-05-10 — — US disclosed
US-20110124621-A1 BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS ASTRAZENECA AB (SE) 2011-05-26 — — US disclosed
EP-2205576-A1 BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS AstraZeneca AB (SE) 2010-07-14 — — EP disclosed
US-20090186870-A1 Therapeutic Agents - 802 ASTRAZENECA AB (SE) 2009-07-23 — — US disclosed
WO-2009047558-A1 BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS ASTRAZENECA AB (SE) 2009-04-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130203730-A1 BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS GPR119, GHSR, GLP1R MEN1 2250/4885KMT2A 1721/4885TDP1 4366/4885
US-20120115845-A1 THERAPEUTIC AGENTS GPR119, MC2R, MC4R MEN1 692/4885KMT2A 3139/4885TDP1 4230/4885
US-20090186870-A1 Therapeutic Agents - 802 GPR119, SLC5A2, MC2R MEN1 1253/4885KMT2A 2304/4885TDP1 4334/4885
US-20150218088-A1 META-DIARYLANILINE OR META-DIARYLPYRIDINAMINE COMPOUND, PREPARATION METHOD AND MEDICAL USES THEREOF QDPR, COMT, CYP2D6 MEN1 619/4885KMT2A 1074/4885TDP1 1093/4885
US-20190322627-A1 AGRICULTURAL CHEMICALS DDT, DHFR, AS3MT MEN1 3345/4885KMT2A 520/4885TDP1 1805/4885
US-20110124621-A1 BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS GPR119, GHSR, GLP1R MEN1 2250/4885KMT2A 1721/4885TDP1 4366/4885
US-11634390-B2 Agricultural chemicals DDT, DHFR, AS3MT MEN1 3345/4885KMT2A 520/4885TDP1 1805/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.