Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | CPN1 | P15169 | 1/20 | 0.33 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | CCR8 | P51685 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7499837 | 0.90 | KMT2A (0.36) | KMT2ASLC6A2SLC6A4SLC6A3OPRM1 | |
| SCHEMBL7493957 | 0.90 | KMT2A (0.36) | KMT2ASLC6A2SLC6A4SLC6A3OPRM1 | |
| SCHEMBL7493966 | 0.90 | KMT2A (0.36) | KMT2ASLC6A2SLC6A4SLC6A3OPRM1 | |
| SCHEMBL7500612 | 0.85 | HTT (0.34) | KMT2ASLC6A2SLC6A4SLC6A3CPN1 | |
| SCHEMBL7966504 | 0.83 | KMT2A (0.34) | KMT2ASLC6A2SLC6A4SLC6A3CPN1 | |
| SCHEMBL7496325 | 0.80 | CACNA2D1 (0.41) | KMT2ASLC6A2SLC6A4SLC6A3OPRM1 | |
| SCHEMBL7491286 | 0.80 | ALDH1A1 (0.40) | OPRM1 | |
| SCHEMBL7505927 | 0.79 | SLC6A2 (0.36) | SLC6A2SLC6A4SLC6A3KCNH2CHRNB2 | |
| SCHEMBL7528853 | 0.79 | POLB (0.43) | KMT2ASLC6A2SLC6A4SLC6A3CPN1 | |
| SCHEMBL7498124 | 0.77 | OPRD1 (0.36) | KMT2ARENSLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002069895-A2 | HETEROCYCLIC ANALGESIC COMPOUNDS AND METHODS OF USE THEREOF | SEPRACOR, INC. (US) | 2002-09-12 | — | — | WO | disclosed |
| EP-1187810-A2 | HETEROCYCLIC ANALGESIC COMPOUNDS AND THEIR USE | SEPRACOR, INC. (US) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000071518-A2 | HETEROCYCLIC ANALGESIC COMPOUNDS AND THEIR USE | SEPRACOR, INC. (US) | 2000-11-30 | — | — | WO | disclosed |