Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7799840 | 0.87 | POLB (0.41) | POLBLMNACCR8GAAKMT2A | |
| SCHEMBL7533916 | 0.86 | HTR6 (0.38) | POLBLMNACCR8KMT2AMAPT | |
| SCHEMBL7531036 | 0.81 | HTR6 (0.43) | LMNAGAAMAPTMCOLN3SMN1; SMN2 | |
| SCHEMBL7500612 | 0.81 | HTT (0.34) | LMNACCR8CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7493966 | 0.80 | KMT2A (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4TSHR | |
| SCHEMBL7493957 | 0.80 | KMT2A (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4TSHR | |
| SCHEMBL7499837 | 0.80 | KMT2A (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4TSHR | |
| SCHEMBL7497433 | 0.79 | KMT2A (0.35) | CCR8CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7966504 | 0.78 | KMT2A (0.34) | CCR8CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7496325 | 0.77 | CACNA2D1 (0.41) | KMT2AMEN1SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002022579-A2 | ANTIPSYCHOTIC SULFONAMIDE-HETEROCYCLES, AND METHODS OF USE THEREOF | SEPRACOR, INC. (US) | 2002-03-21 | — | — | WO | disclosed |