Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | BRS3 | P32247 | 3/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8664812 | 0.85 | BRS3 (0.38) | LMNAMAPK1BRS3SMN1; SMN2AURKA | |
| SCHEMBL8325612 | 0.78 | LMNA (0.43) | LMNABRS3SLC22A12SMN1; SMN2AURKA | |
| SCHEMBL6580558 | 0.77 | SLC22A12 (0.42) | LMNABRS3SLC22A12SMN1; SMN2AURKA | |
| SCHEMBL7501841 | 0.74 | SLC22A12 (0.38) | LMNAMAPK1SLC22A12SMN1; SMN2ALDH1A1 | |
| SCHEMBL6580573 | 0.74 | BRS3 (0.42) | LMNABRS3SLC22A12SMN1; SMN2AURKA | |
| SCHEMBL7502700 | 0.71 | EDNRA (0.43) | BRS3SMN1; SMN2ALDH1A1TP53HPGD | |
| SCHEMBL7499419 | 0.71 | EDNRA (0.45) | BRS3SMN1; SMN2AURKACSNK1EGSK3A | |
| SCHEMBL8432538 | 0.71 | EDNRA (0.40) | LMNABRS3MAPT | |
| SCHEMBL8792168 | 0.71 | EDNRA (0.41) | LMNABRS3AURKACSNK1EGSK3A | |
| SCHEMBL8434687 | 0.69 | BRS3 (0.39) | LMNABRS3SLC22A12MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0776325-B1 | NOVEL USE AND NOVEL DERIVATIVES OF IMIDAZOLE, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2002-11-20 | — | — | EP | disclosed |
| WO-1996004276-A1 | NOVEL USE AND NOVEL DERIVATIVES OF IMIDAZOLE, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | ROUSSEL UCLAF (FR) | 1996-02-15 | — | — | WO | disclosed |