Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | CSF1R | P07333 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | FLT4 | P35916 | 2/20 | 0.40 |
| ▸ | CLK2 | P49760 | 2/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | STK3 | Q13188 | 2/20 | 0.40 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.40 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7509556 | 0.86 | MAPK14 (0.42) | HTR1AADRA1DADRA1AADRA1BPDE4B | |
| SCHEMBL7500922 | 0.85 | ALDH1A1 (0.57) | HTR1AADRA1DADRA1AADRA1BPDE4B | |
| SCHEMBL7501246 | 0.81 | HTR1A (0.53) | HTR1AADRA1DADRA1AADRA1BKDM4E | |
| SCHEMBL7510365 | 0.80 | HTR1A (0.65) | HTR1AADRA1DADRA1AADRA1BPDE4B | |
| SCHEMBL7497416 | 0.80 | HTR1A (0.44) | HTR1AADRA1DADRA1AADRA1BKDM4E | |
| SCHEMBL7506544 | 0.80 | HTR1A (0.50) | HTR1AADRA1DADRA1AADRA1BKDM4E | |
| SCHEMBL7504497 | 0.79 | LMNA (0.56) | HTR1AADRA1DADRA1AADRA1BKDM4E | |
| SCHEMBL7512180 | 0.79 | HTR1A (0.45) | HTR1AADRA1DADRA1AADRA1BKDM4E | |
| SCHEMBL7503432 | 0.78 | RAB9A (0.39) | HTR1AADRA1DADRA1AADRA1BKDM4E | |
| SCHEMBL7512679 | 0.77 | CYP1A2 (0.51) | HTR1AADRA1DADRA1AADRA1BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0326331-B1 | Substituted quinolines and cinnolines | DOW AGROSCIENCES LLC (US) | 2002-04-17 | — | — | EP | disclosed |
| CN-1034204-C | Substituted quinolines and cinnolines | LILLY CO ELI (US) | 1997-03-12 | — | — | CN | disclosed |
| US-5294622-A | Fungicides, insecticides, miticides | DOWELANCO (US) | 1994-03-15 | — | — | US | disclosed |
| US-5114939-A | Amine or ether substitutes compounds of quinoline or cinnoline | DOWELANCO (US) | 1992-05-19 | — | — | US | disclosed |
| EP-0326331-A2 | Substituted quinolines and cinnolines | DowElanco (US) | 1989-08-02 | — | — | EP | disclosed |