Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 6/20 | 0.34 |
| ▸ | EDNRB | P24530 | 5/20 | 0.34 |
| ▸ | CKS1B | P61024 | 1/20 | 0.34 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.34 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7408121 | 0.76 | HPGDS (0.44) | HPGDHPGDSEDNRAEDNRBPIN1 | |
| SCHEMBL7506363 | 0.74 | EDNRA (0.44) | EDNRAEDNRB | |
| SCHEMBL8547875 | 0.69 | CA2 (0.45) | HPGDSSCN9AIKBKBCA12CA1 | |
| SCHEMBL8908994 | 0.69 | MAOB (0.47) | HPGDIMPDH2HPGDSEDNRAEDNRB | |
| SCHEMBL8566288 | 0.68 | EDNRB (0.44) | EDNRAEDNRBCKS1BGLO1SKP2 | |
| SCHEMBL1804383 | 0.68 | HPGDS (0.56) | IMPDH2HPGDSEDNRAEDNRBBRD4 | |
| SCHEMBL5822874 | 0.65 | PTGS2 (0.54) | IKBKBCA12CA1CA2CA9 | |
| SCHEMBL7506365 | 0.65 | EDNRA (0.45) | EDNRAEDNRB | |
| SCHEMBL9510279 | 0.64 | HPGDS (0.58) | HPGDIMPDH2HPGDSEDNRAEDNRB | |
| SCHEMBL6026444 | 0.64 | BRD4 (0.43) | HPGDSEDNRAEDNRBBRD4LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921800-A4 | SUBSTITUTED BIPHENYL ISOXAZOLE SULFONAMIDES | BRISTOL MYERS SQUIBB CO (US) | 2000-12-06 | — | — | EP | disclosed |
| EP-0921800-A1 | SUBSTITUTED BIPHENYL ISOXAZOLE SULFONAMIDES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-06-16 | — | — | EP | disclosed |
| WO-1997029748-A1 | SUBSTITUTED BIPHENYL ISOXAZOLE SULFONAMIDES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-08-21 | — | — | WO | disclosed |