Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | WEE1 | P30291 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7516495 | 0.94 | ALDH1A1 (0.36) | BTKACVR1GAAMEN1KMT2A | |
| SCHEMBL7824786 | 0.92 | DRD2 (0.37) | GAAITGB3ITGA2BMEN1KMT2A | |
| SCHEMBL7827942 | 0.90 | DRD2 (0.45) | GAAITGB3ITGA2BMEN1KMT2A | |
| SCHEMBL7818532 | 0.90 | L3MBTL3 (0.38) | BTKGAAITGB3ITGA2BMEN1 | |
| SCHEMBL7827664 | 0.87 | ROCK2 (0.38) | DRD2KDM4E | |
| SCHEMBL7829164 | 0.81 | HRH3 (0.35) | BTKUSP2ALDH1A1KDM4E | |
| SCHEMBL7512428 | 0.77 | L3MBTL3 (0.31) | — | |
| SCHEMBL7510864 | 0.77 | — | — | |
| SCHEMBL7480136 | 0.77 | MAPT (0.33) | GAAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL7517482 | 0.76 | MAOA (0.40) | KMT2AMAPTHTTPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861250-B1 | AMIDINE AND ISOTHIOUREA DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2002-02-13 | — | — | EP | claimed |