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Cortisone Acetate

Cortisone Acetate

SCHEMBL7518922

CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3C(=O)C[C@@]21C.C[C@]12C=CC(=O)C=C1C(Cl)=C[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Cortisone Acetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 6/20 0.64
▸ PGR P06401 5/20 0.64
▸ FNTA P49354 4/20 0.64
▸ FNTB P49356 4/20 0.64
▸ KMT2A Q03164 4/20 0.64
▸ AR P10275 2/20 0.64
▸ TSHR P16473 2/20 0.64
▸ MEN1 O00255 2/20 0.64
▸ MLNR O43193 1/20 0.64
▸ NR1I2 O75469 1/20 0.64
▸ ADORA3 P0DMS8 1/20 0.64
▸ HTR2C P28335 1/20 0.64
▸ BLM P54132 1/20 0.64
▸ HIF1A Q16665 6/20 0.59
▸ SERPINA6 P08185 3/20 0.59
▸ LMNA P02545 3/20 0.59
▸ CHRM1 P11229 1/20 0.59
▸ HSD17B10 Q99714 8/20 0.58
▸ SHBG P04278 2/20 0.58
▸ CYP3A4 P08684 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cloprednol SCHEMBL3999177 0.95 NR3C1 (0.71) NR3C1PGRFNTAFNTBKMT2A
Cortisone Acetate SCHEMBL17966400 0.88 HIF1A (0.74) NR3C1PGRFNTAFNTBKMT2A
Cortisone Acetate SCHEMBL19463056 0.85 HIF1A (0.81) NR3C1PGRFNTAFNTBKMT2A
Cortisone Acetate SCHEMBL19463054 0.85 HIF1A (0.81) NR3C1PGRFNTAFNTBKMT2A
Prednisolone SCHEMBL11710056 0.82 HSD17B10 (0.76) NR3C1PGRFNTAFNTBKMT2A
Cloprednol SCHEMBL19327143 0.80 PGR (1.00) NR3C1PGRKMT2AARMEN1
Cloprednol SCHEMBL4886 0.80 PGR (1.00) NR3C1PGRKMT2AARMEN1
Cortisone Acetate SCHEMBL9819561 0.80 FNTA (1.00) NR3C1PGRFNTAFNTBKMT2A
Cloprednol SCHEMBL11209368 0.80 PGR (1.00) NR3C1PGRKMT2AARMEN1
Cortisone Acetate SCHEMBL9819556 0.80 FNTA (1.00) NR3C1PGRFNTAFNTBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001010907-A9 THERAPEUTIC POLYPEPTIDES AND METHODS FOR USING SAME UNIV MARYLAND BIOTECH INST (US) 2002-07-11 — — WO disclosed