Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 1/20 | 0.45 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA4 | P22748 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7511207 | 0.96 | HPGD (0.47) | GABRA1GABRB2HPGDKDM4EALDH1A1 | |
| SCHEMBL31107078 | 0.96 | HPGD (0.47) | GABRA1GABRB2HPGDKDM4EALDH1A1 | |
| Water SCHEMBL7529567 | 0.94 | HPGD (0.45) | GABRA1GABRB2HPGDKDM4EALDH1A1 | |
| SCHEMBL11349953 | 0.78 | LMNA (0.54) | GABRA1GABRB2HPGDKDM4EALDH1A1 | |
| SCHEMBL31107080 | 0.78 | LMNA (0.54) | GABRA1GABRB2HPGDKDM4EALDH1A1 | |
| SCHEMBL974064 | 0.78 | LMNA (0.54) | GABRA1GABRB2HPGDKDM4EALDH1A1 | |
| SCHEMBL974062 | 0.78 | LMNA (0.54) | GABRA1GABRB2HPGDKDM4EALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL7523599 | 0.77 | LMNA (0.52) | GABRA1GABRB2HPGDKDM4EALDH1A1 | |
| SCHEMBL7522058 | 0.77 | LMNA (0.52) | GABRA1GABRB2HPGDKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL1375900 | 0.77 | LMNA (0.52) | GABRA1GABRB2HPGDKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6359172-B1 | Method of preparing 2- and 4-hydroxymandelic acid | GERARD KESSELS SOCIEDAD ANONIMA, S.A. (ES) | 2002-03-19 | — | — | US | disclosed |
| EP-0987245-B1 | A method of preparing 2- and 4-hydroxymandelic acid | GERARD KESSELS S A (ES) | 2002-03-13 | — | — | EP | disclosed |
| EP-0987245-A1 | A method of preparing 2- and 4-hydroxymandelic acid | Gerard Kessels S.A. (ES) | 2000-03-22 | — | — | EP | disclosed |