SCHEMBL7523209

SCHEMBL7523209

Cc1cccc([SiH2]CSc2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)c1C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 1/20 0.41
GABRB2 P47870 1/20 0.41
HPN P05981 1/20 0.41
MAPT P10636 1/20 0.41
ALOX15 P16050 1/20 0.41
SIRT5 Q9NXA8 1/20 0.41
CA2 P00918 3/20 0.38
SCN2A Q99250 2/20 0.38
SMN1; SMN2 Q16637 3/20 0.37
ALDH1A1 P00352 2/20 0.37
POLB P06746 1/20 0.37
TYR P14679 1/20 0.37
CYP2C9 P11712 4/20 0.34
CYP2C19 P33261 4/20 0.34
CA1 P00915 1/20 0.34
TRPA1 O75762 1/20 0.34
ATM Q13315 1/20 0.34
CYP1A2 P05177 1/20 0.34
PTGS1 P23219 2/20 0.33
PTGS2 P35354 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8390355 0.95 GABRA1 (0.42) GABRA1GABRB2HPNMAPTALOX15
SCHEMBL7525374 0.87 ALDH1A1 (0.36) GABRA1GABRB2MAPTALOX15SMN1; SMN2
SCHEMBL8389494 0.83 CA2 (0.42) GABRA1GABRB2HPNMAPTALOX15
SCHEMBL7519263 0.79 SCN2A (0.43) GABRA1GABRB2HPNMAPTALOX15
SCHEMBL5692154 0.79 GABRA1 (0.41) GABRA1GABRB2CA2TRPA1ATM
SCHEMBL27535171 0.77 ESR1 (0.39) MAPTCA2SMN1; SMN2ALDH1A1CYP2C19
SCHEMBL6676515 0.77 SCN2A (0.43) GABRA1GABRB2MAPTALOX15CA2
SCHEMBL27515458 0.73 ESR1 (0.34) GABRA1GABRB2MAPTTRPA1ATM
SCHEMBL27497914 0.72 THRA (0.36) GABRA1GABRB2MAPTPOLBTRPA1
SCHEMBL7526769 0.71 TRPA1 (0.37) MAPTALOX15ALDH1A1CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0900225-B1 ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS AVENTIS PHARMA INC (US) 2002-01-30 EP claimed
EP-0910384-A1 METHOD OF INHIBITING VASCULAR CELL ADHESION MOLECULE-1 AND TREATING CHRONIC INFLAMMATORY DISEASES WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS HOECHST MARION ROUSSEL, INC. (US) 1999-04-28 EP claimed
WO-1997040837-A1 METHOD OF INHIBITING VASCULAR CELL ADHESION MOLECULE-1 AND TREATING CHRONIC INFLAMMATORY DISEASES WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS HOECHST MARION ROUSSEL, INC. (US) 1997-11-06 WO claimed
EP-0900225-B1 ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS AVENTIS PHARMA INC (US) 2002-01-30 EP disclosed
US-6133467-A ANTIATHEROSCLEROTIC AGENTS HOECHST MARION ROUSSEL, INC. (US) 2000-10-17 US disclosed
EP-0996623-A1 2,6-DI-t-BUTYL-4- (DIMETHYL-4-METHOXYPHENYLSILYL) -METHYLOXY]PHENOL AND 2,6-DI-t-BUTYL-4- (DIMETHYL-2-METHOXY-PHENYLSILYL) -METHYLOXY]PHENOL HOECHST MARION ROUSSEL, INC. (US) 2000-05-03 EP disclosed
EP-0910384-A1 METHOD OF INHIBITING VASCULAR CELL ADHESION MOLECULE-1 AND TREATING CHRONIC INFLAMMATORY DISEASES WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS HOECHST MARION ROUSSEL, INC. (US) 1999-04-28 EP disclosed
WO-1998058937-A1 2,6-DI-t-BUTYL-4-[ (DIMETHYL-4-METHOXYPHENYLSILYL) -METHYLOXY]PHENOL AND 2,6-DI-t-BUTYL-4-[ (DIMETHYL-2-METHOXY-PHENYLSILYL) -METHYLOXY]PHENOL HOECHST MARION ROUSSEL, INC. (US) 1998-12-30 WO disclosed
WO-1997040837-A1 METHOD OF INHIBITING VASCULAR CELL ADHESION MOLECULE-1 AND TREATING CHRONIC INFLAMMATORY DISEASES WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS HOECHST MARION ROUSSEL, INC. (US) 1997-11-06 WO disclosed
US-5608095-A Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents HOECHST MARION ROUSSEL, INC. (US) 1997-03-04 US disclosed