Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25237284 | 0.80 | MEN1 (0.39) | ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL2776281 | 0.79 | TSHR (0.36) | ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL8940602 | 0.78 | ALDH1A1 (0.35) | ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL5159378 | 0.78 | ALDH1A1 (0.35) | ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL11127704 | 0.78 | ALDH1A1 (0.59) | ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL33780 | 0.78 | THRB (0.52) | ALDH1A1TSHRMEN1KMT2A | |
| Potassium Ion SCHEMBL5759726 | 0.77 | MEN1 (0.33) | MEN1KMT2A | |
| SCHEMBL8701814 | 0.75 | MEN1 (0.33) | ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL16708633 | 0.74 | TSHR (0.37) | ALDH1A1TSHRMEN1KMT2A | |
| Acetic Acid SCHEMBL28158415 | 0.74 | THRB (0.48) | ALDH1A1TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430013-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | Amgen, Inc (US) | 2012-03-21 | — | — | EP | disclosed |