Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | CCR8 | P51685 | 2/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7528853 | 0.87 | POLB (0.43) | POLBLMNASMN1; SMN2RAB9AMAPK1 | |
| SCHEMBL7533916 | 0.73 | HTR6 (0.38) | POLBLMNASMN1; SMN2KMT2AMAPT | |
| SCHEMBL27565064 | 0.72 | SLC6A2 (0.38) | POLBLMNAOPRD1SLC6A2SLC6A4 | |
| SCHEMBL8501565 | 0.71 | MMP1 (0.36) | OPRD1SLC6A2SLC6A4MMP1MMP3 | |
| Iodide SCHEMBL4792332 | 0.70 | OPRD1 (0.36) | OPRD1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7797107 | 0.70 | NPR3 (0.42) | OPRD1MAPK1KMT2AMAPTSLC6A2 | |
| Iodide SCHEMBL4349226 | 0.70 | OPRD1 (0.36) | OPRD1SLC6A2SLC6A4SLC6A3 | |
| Iodide SCHEMBL4490791 | 0.69 | OPRD1 (0.36) | OPRD1MAPTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL12469312 | 0.68 | SLC6A2 (0.46) | SMN1; SMN2RAB9AKMT2AMEN1SLC6A2 | |
| SCHEMBL8703070 | 0.68 | ITGA4 (0.42) | POLBSMN1; SMN2KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010039286-A1 | 2-aryl indole derivatives and their use as therapeutic agents | DINNELL KEVIN (GB) | 2001-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010039286-A1 | 2-aryl indole derivatives and their use as therapeutic agents | IDO1, IDO2, CNR2 | POLB 2886/4885LMNA 2005/4885OPRD1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.