Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.76 |
| ▸ | MEN1 | O00255 | 5/20 | 0.76 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.76 |
| ▸ | RECQL | P46063 | 2/20 | 0.76 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.76 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.74 |
| ▸ | STS | P08842 | 3/20 | 0.73 |
| ▸ | CA1 | P00915 | 1/20 | 0.73 |
| ▸ | CA2 | P00918 | 1/20 | 0.73 |
| ▸ | CA9 | Q16790 | 1/20 | 0.73 |
| ▸ | ESR1 | P03372 | 6/20 | 0.72 |
| ▸ | MAPT | P10636 | 6/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.72 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.72 |
| ▸ | PGR | P06401 | 3/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14305721 | 1.00 | LMNA (0.76) | LMNAKMT2ACYP3A4MEN1ALOX15 | |
| SCHEMBL27369500 | 1.00 | LMNA (0.76) | LMNAKMT2ACYP3A4MEN1ALOX15 | |
| SCHEMBL18658846 | 1.00 | LMNA (0.76) | LMNAKMT2ACYP3A4MEN1ALOX15 | |
| SCHEMBL14951243 | 1.00 | LMNA (0.76) | LMNAKMT2ACYP3A4MEN1ALOX15 | |
| SCHEMBL13596253 | 0.91 | LMNA (0.76) | LMNAKMT2ACYP3A4MEN1ALOX15 | |
| SCHEMBL26073723 | 0.89 | LMNA (0.74) | LMNAKMT2ACYP3A4MEN1ALOX15 | |
| SCHEMBL17399530 | 0.89 | STS (0.75) | LMNAKMT2ACYP3A4MEN1ALOX15 | |
| SCHEMBL9144806 | 0.89 | LMNA (0.70) | LMNAKMT2ACYP3A4MEN1ALOX15 | |
| SCHEMBL22675144 | 0.88 | KMT2A (0.76) | LMNAKMT2ACYP3A4MEN1ALOX15 | |
| SCHEMBL7538281 | 0.88 | KMT2A (0.76) | LMNAKMT2ACYP3A4MEN1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6083941-A | TREATMENT OF NEUROPATHIC PAIN, DRUG WITHDRAWAL/DEPENDENCY, EPILEPSY, GLAUCOMA, CHRONIC NEURODEGENERATIVE DISEASES, AMYOTROPHIC LATERAL SCLEROSIS, ANXIETY DISORDERS, BRAIN CELL DEATH, ISCHAEMIA, STROKE, TRAUMA | TRUSTEES OF BOSTON UNIVERSITY (US) | 2000-07-04 | — | — | US | claimed |
| US-11384114-B2 | Polymorphic forms of an oxysterol and methods of making them | WARSAW ORTHOPEDIC, INC. (US) | 2022-07-12 | — | — | US | disclosed |
| EP-3827833-B1 | METHODS FOR THE SEPARATION AND DETECTION OF AN OXYSTEROL | WARSAW ORTHOPEDIC INC (US) | 2022-06-15 | — | — | EP | disclosed |
| US-11324759-B2 | Oxysterol-statin compounds for bone growth | WARSAW ORTHOPEDIC, INC. (US) | 2022-05-10 | — | — | US | disclosed |
| US-11234991-B2 | Methods for the separation and detection of an oxysterol | WARSAW ORTHOPEDIC, INC. (US) | 2022-02-01 | — | — | US | disclosed |
| CN-113603741-A | Compounds and methods relating to sterols | 华沙整形外科股份有限公司 | 2021-11-05 | — | — | CN | disclosed |
| US-20210238218-A1 | COMPOUNDS AND METHODS OF MAKING STEROLS USING DIOLS | WARSAW ORTHOPEDIC INC (US) | 2021-08-05 | — | — | US | disclosed |
| CN-107427526-B | Compounds and methods relating to sterols | 华沙整形外科股份有限公司 | 2021-08-03 | — | — | CN | disclosed |
| EP-3831838-A1 | OXYSTEROL-STATIN COMPOUNDS FOR BONE GROWTH | Warsaw Orthopedic, Inc. (US) | 2021-06-09 | — | — | EP | disclosed |
| EP-3827833-A1 | METHODS FOR THE SEPARATION AND DETECTION OF AN OXYSTEROL | Warsaw Orthopedic, Inc. (US) | 2021-06-02 | — | — | EP | disclosed |
| WO-2016094421-A1 | COMPOUNDS AND METHODS INVOLVING STEROLS | WARSAW ORTHOPEDIC, INC. (US) | 2016-06-16 | — | — | WO | disclosed |
| US-20160159848-A1 | COMPOUNDS AND METHODS INVOLVING STEROLS | WARSAW ORTHOPEDIC, INC. | 2016-06-09 | — | — | US | disclosed |
| US-20160159849-A1 | COMPOUNDS AND METHODS OF MAKING STEROLS USING DIOLS | WARSAW ORTHOPEDIC, INC. | 2016-06-09 | — | — | US | disclosed |
| US-20160161473-A1 | BIOTIN CONJUGATES OF ANALYTES CONTAINING AMINO, HYDROXYL, OR THIOL FUNCTIONAL GROUPS FOR USE IN IMMUNODIAGNOSTIC ASSAYS | Calbiotech, Inc. | 2016-06-09 | — | — | US | disclosed |
| US-20020035100-A1 | Alkyl ether modified polycyclic compounds having a terminal phenol and uses for protection of cells | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2002-03-21 | — | — | US | disclosed |
| US-6083941-A | TREATMENT OF NEUROPATHIC PAIN, DRUG WITHDRAWAL/DEPENDENCY, EPILEPSY, GLAUCOMA, CHRONIC NEURODEGENERATIVE DISEASES, AMYOTROPHIC LATERAL SCLEROSIS, ANXIETY DISORDERS, BRAIN CELL DEATH, ISCHAEMIA, STROKE, TRAUMA | TRUSTEES OF BOSTON UNIVERSITY (US) | 2000-07-04 | — | — | US | disclosed |
| US-5861388-A | TREATMENT OF ESTROGEN DEPENDENT DISORDERS AS FOR EXAMPLEBREAST CANCER | SRI INTERNATIONAL (US) | 1999-01-19 | — | — | US | disclosed |
| US-5763432-A | TREATMENT OF ESTROGEN-DEPENDENT DISORDERS | SRI INTERNATIONAL (US) | 1998-06-09 | — | — | US | disclosed |
| EP-0840612-A1 | INHIBITION OF NMDA RECEPTOR ACTIVITY BY PREGNENOLONE SULFATE DERIVATIVES | TRUSTEES OF BOSTON UNIVERSITY (US) | 1998-05-13 | — | — | EP | disclosed |
| WO-1997003677-A1 | INHIBITION OF NMDA RECEPTOR ACTIVITY BY PREGNENOLONE SULFATE DERIVATIVES | TRUSTEES OF BOSTON UNIVERSITY (US) | 1997-02-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160159849-A1 | COMPOUNDS AND METHODS OF MAKING STEROLS USING DIOLS | DHCR7, LSS, HSD17B7 | LMNA 1545/4885KMT2A 4327/4885CYP3A4 131/4885 |
| US-20160159848-A1 | COMPOUNDS AND METHODS INVOLVING STEROLS | LSS, DHCR7, HSD17B7 | LMNA 1699/4885KMT2A 4497/4885CYP3A4 120/4885 |
| US-11234991-B2 | Methods for the separation and detection of an oxysterol | OSBP2, NR1H3, OSBP | LMNA 554/4885KMT2A 4870/4885CYP3A4 556/4885 |
| US-11324759-B2 | Oxysterol-statin compounds for bone growth | HMGCR, SOST, OSBP2 | LMNA 3608/4885KMT2A 4672/4885CYP3A4 350/4885 |
| US-11384114-B2 | Polymorphic forms of an oxysterol and methods of making them | HSD3B1, VKORC1L1, VKORC1 | LMNA 874/4885KMT2A 4813/4885CYP3A4 60/4885 |
| US-20210238218-A1 | COMPOUNDS AND METHODS OF MAKING STEROLS USING DIOLS | DHCR7, LSS, HSD17B7 | LMNA 1545/4885KMT2A 4327/4885CYP3A4 131/4885 |
| US-20160161473-A1 | BIOTIN CONJUGATES OF ANALYTES CONTAINING AMINO, HYDROXYL, OR THIOL FUNCTIONAL GROUPS FOR USE IN IMMUNODIAGNOSTIC ASSAYS | SHBG, BTD, CYP24A1 | LMNA 2482/4885KMT2A 3063/4885CYP3A4 608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.