Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.55 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9136443 | 0.85 | ALOX5 (0.45) | ACHESLC22A1CHRM2SLC6A4OPRM1 | |
| SCHEMBL3271844 | 0.83 | SLC6A4 (0.50) | ACHESLC22A1CHRM2SLC6A4OPRM1 | |
| SCHEMBL23333048 | 0.81 | ACHE (0.55) | ACHESLC22A1CHRM2SLC6A4OPRM1 | |
| SCHEMBL14513169 | 0.79 | ALDH1A1 (0.50) | SLC6A4CYP2D6 | |
| SCHEMBL9250652 | 0.78 | OPRM1 (0.44) | ACHESLC22A1CHRM2SLC6A4OPRM1 | |
| SCHEMBL9138011 | 0.78 | OPRD1 (0.63) | OPRM1ALOX5OPRD1 | |
| SCHEMBL9219871 | 0.76 | OPRD1 (0.44) | SLC6A4OPRM1ALOX5OPRD1 | |
| SCHEMBL19145625 | 0.76 | ACHE (0.77) | ACHESLC22A1CHRM2SLC6A4OPRM1 | |
| SCHEMBL1599480 | 0.74 | ALOX5 (0.54) | ALOX5OPRD1 | |
| SCHEMBL9136365 | 0.73 | OPRD1 (0.42) | ACHESLC22A1CHRM2SLC6A4OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1250332-A1 | INHIBITORS OF INTERLEUKIN 5 GENE EXPRESSION | Abbott Laboratories (US) | 2002-10-23 | — | — | EP | disclosed |
| WO-2001044223-A1 | INHIBITORS OF INTERLEUKIN 5 GENE EXPRESSION | ABBOTT LABORATORIES (US) | 2001-06-21 | — | — | WO | disclosed |
| EP-0462830-B1 | Cyclic ether derivatives | ZENECA LTD (GB) | 1995-10-18 | — | — | EP | disclosed |
| US-5407945-A | Pyran derivatives and their use as inhibitors of 5-lipoxygenase | IMPERIAL CHEMICAL INDUSTRIES, INC. (GB) | 1995-04-18 | — | — | US | disclosed |
| US-5254581-A | Used in the treatment of various inflammatory and allergic diseases | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-10-19 | — | — | US | disclosed |
| EP-0462830-A2 | Cyclic ether derivatives | ZENECA LIMITED (GB) | 1991-12-27 | — | — | EP | disclosed |