SCHEMBL7543266

SCHEMBL7543266

[CH]1C2C=CC(C2)C1(c1ccccc1)c1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAOB P27338 8/20 0.33
MAOA P21397 5/20 0.33
HSD11B1 P28845 1/20 0.33
GRIN2D O15399 1/20 0.31
GRIN3B O60391 1/20 0.31
GRIN1 Q05586 1/20 0.31
GRIN2A Q12879 1/20 0.31
GRIN2B Q13224 1/20 0.31
GRIN2C Q14957 1/20 0.31
GRIN3A Q8TCU5 1/20 0.31
KDM1A O60341 2/20 0.31
MEN1 O00255 1/20 0.31
ALDH1A1 P00352 1/20 0.31
POLB P06746 1/20 0.31
KMT2A Q03164 1/20 0.31
CTDSP1 Q9GZU7 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1741105 0.69 MAOB (0.39) MAOBMAOAGRIN2DGRIN3BGRIN1
SCHEMBL29067577 0.62 OPRM1 (0.37) MAOBMAOA
SCHEMBL4248753 0.62 MAOA (0.34) MAOBMAOAKDM1AALDH1A1TDP1
SCHEMBL1733128 0.62 ALDH1A1 (0.39) MEN1ALDH1A1POLBKMT2ACTDSP1
SCHEMBL11740261 0.61 MAOB (0.36) MAOBMAOAGRIN2DGRIN3BGRIN1
SCHEMBL1732686 0.61 OPRM1 (0.33) MAOBMAOAKDM1AMEN1ALDH1A1
SCHEMBL745582 0.59 PTGS2 (0.44) MAOBMAOAMEN1KMT2A
SCHEMBL1732130 0.59 MAOB (0.52) MAOBMAOAKDM1A
SCHEMBL231895 0.59 MAOA (0.41) MAOBMAOAKDM1A
SCHEMBL1732423 0.59 MAOB (0.34) MAOBMAOAGRIN2DGRIN3BGRIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6476240-B2 POLYMERS DERIVED FROM AN UNSATURATED FUSED CYCLIC HYDROCARBON (SUCH AS PERHYDRO-2,3-DIDEHYDRO-1,4:5,8-DIMETHANONAPHTHALENE) JOINED BY A LINKER TO AN ESTER GROUP HAVING ONE OR TWO PROTECTED HYDROXYLS; USE AS PHOTORESIST WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) 2002-11-05 US disclosed
US-20020042531-A1 Polymers derived from an unsaturated fused cyclic hydrocarbon (such as perhydro-2,3-didehydro-1,4:5,8-dimethanonaphthalene) joined by a linker to an ester group having one or two protected hydroxyls; use as photoresist WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) 2002-04-11 US disclosed
US-6331602-B1 Monomer and a polymer obtained therefrom WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) 2001-12-18 US disclosed
US-6160068-A Monomer and a polymer obtained therefrom WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) 2000-12-12 US disclosed
EP-0918048-A1 A novel monomer and a polymer obtained therefrom Wako Pure Chemical Industries, Ltd. (JP) 1999-05-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020042531-A1 Polymers derived from an unsaturated fused cyclic hydrocarbon (such as perhydro-2,3-didehydro-1,4:5,8-dimethanonaphthalene) joined by a linker to an ester group having one or two protected hydroxyls; use as photoresist AHR, DHCR24, FPR1 MAOB 4221/4885MAOA 4041/4885HSD11B1 160/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.