SCHEMBL7545075

SCHEMBL7545075

CCCn1cc(CCc2ccccc2)c(C2CCN(Cc3ccccc3)CC2)n1

nearest known ligand 0.56

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CCR5 P51681 3/20 0.56
ACHE P22303 1/20 0.44
POLB P06746 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
DRD2 P14416 5/20 0.42
DRD4 P21917 4/20 0.42
DRD3 P35462 4/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
NPSR1 Q6W5P4 1/20 0.41
ABL1 P00519 1/20 0.40
RIN1 Q13671 1/20 0.40
CCR3 P51677 1/20 0.40
OPRM1 P35372 1/20 0.40
ALDH1A1 P00352 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
TSHR P16473 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7544127 0.80 CCR5 (0.54) CCR5ACHEPOLBTDP1DRD2
SCHEMBL7547655 0.77 CCR5 (0.56) CCR5ACHEPOLBTDP1DRD2
SCHEMBL7493953 0.72 DRD2 (0.46) CCR5ACHEDRD2DRD4DRD3
SCHEMBL5764111 0.72 CCR5 (0.54) CCR5ACHEPOLBTDP1DRD2
SCHEMBL7500129 0.68 ACHE (0.46) CCR5ACHEDRD2DRD4DRD3
SCHEMBL8572563 0.67 POLB (0.48) ACHEPOLBTDP1DRD2DRD4
SCHEMBL8274394 0.67 LMNA (0.52) ACHEDRD2DRD4DRD3MEN1
SCHEMBL8097472 0.66 SIGMAR1 (0.72) ACHEPOLBDRD2DRD4CCR3
SCHEMBL6744977 0.66 SIGMAR1 (0.72) ACHEPOLBDRD2DRD4CCR3
SCHEMBL5633507 0.66 ACHE (0.54) ACHEPOLBTDP1DRD2DRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1171122-A4 PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO INC (US) 2002-05-29 EP disclosed
EP-1171122-A1 PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Merck & Co., Inc. (US) 2002-01-16 EP disclosed
US-6248755-B1 ANTIINFLAMMATORY AGENTS; ANTIALLERGENS; AUTOIMMUNE DISEASES MERCK & CO., INC. 2001-06-19 US disclosed
WO-2000059502-A1 PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2000-10-12 WO disclosed