Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 5/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | HTR2B | P41595 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | IDH2 | P48735 | 1/20 | 0.32 |
| ▸ | RHEB | Q15382 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9425517 | 0.79 | HTR1A (0.39) | ADRB1HTR6AHRPIK3CDADRB2 | |
| SCHEMBL1254418 | 0.78 | KDM1A (0.45) | HTR6HTR2AHTR1AMAPK1 | |
| SCHEMBL4721303 | 0.75 | NISCH (0.36) | HTR2CHTR2AHTR2BHTR1AKCNH2 | |
| SCHEMBL10491761 | 0.73 | JAK2 (0.46) | ADRB1HTR6HTR2CADRB2HTR2A | |
| SCHEMBL1255263 | 0.72 | HTR2C (0.50) | ADRB1HTR6HTR2CHTR2AHTR2B | |
| SCHEMBL1255256 | 0.72 | HTR2C (0.42) | ADRB1HTR6HTR2CHTR2AHTR2B | |
| SCHEMBL9703831 | 0.72 | DRD2 (0.46) | ADRB1HTR6AHRHTR2AHTR1A | |
| Hydrochloric Acid SCHEMBL11136214 | 0.72 | JAK2 (0.45) | ADRB1HTR6HTR2CADRB2HTR2A | |
| SCHEMBL2204913 | 0.71 | HTR2C (0.47) | HTR2CHTR2AHTR2BHTR1A | |
| SCHEMBL3549378 | 0.71 | KDM1A (0.42) | HTR2CHTR2AHTR2BHTR1ACHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-8319274-A | — | — | None | — | — | JP | disclosed |
| US-20120214798-A1 | Novel Ethanediamone Hepcidine Antagonists | VIFOR (INTERNATIONAL) AG (CH) | 2012-08-23 | — | — | US | disclosed |
| EP-0737678-B1 | 4-Indolylpiperazinyl derivatives | AMERICAN HOME PROD (US) | 2002-06-19 | — | — | EP | disclosed |
| EP-0737678-B1 | 4-Indolylpiperazinyl derivatives | AMERICAN HOME PROD (US) | 2002-06-19 | — | — | EP | disclosed |
| JP-H08319274-A | 4-INDOLYLPIPERAZINYL DERIVATIVE | AMERICAN HOME PROD CORP | 1996-12-03 | — | — | JP | disclosed |
| EP-0737677-A1 | 4-Indolylpiperazinyl derivates | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-10-16 | — | — | EP | disclosed |
| EP-0737678-A1 | 4-Indolylpiperazinyl derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-10-16 | — | — | EP | disclosed |
| EP-0737678-A1 | 4-Indolylpiperazinyl derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-10-16 | — | — | EP | disclosed |
| US-5519025-A | 4-indolylpiperazinyl derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-05-21 | — | — | US | disclosed |
| US-5486518-A | 4-indolylpiperazinyl derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214798-A1 | Novel Ethanediamone Hepcidine Antagonists | HAMP, SLC40A1, FTH1 | ADRB1 907/4885HTR6 1733/4885AHR 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.