Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.33 |
| ▸ | OXTR | P30559 | 1/20 | 0.33 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7550390 | 0.88 | KEAP1 (0.42) | MAPK14KEAP1LMNAESR1NPC1 | |
| SCHEMBL7548664 | 0.86 | KEAP1 (0.36) | MAPK14KEAP1CHRNA7POLBKDR | |
| SCHEMBL7544426 | 0.84 | HPGD (0.42) | MAPK14MAPK13MAPK12MAPK11LMNA | |
| SCHEMBL8609973 | 0.84 | KMT2A (0.34) | MAPK14MAPK13MAPK12MAPK11KEAP1 | |
| SCHEMBL7548471 | 0.81 | MAPK13 (0.41) | MAPK14MAPK13MAPK12MAPK11NOS3 | |
| SCHEMBL9059987 | 0.81 | SGMS2 (0.35) | CHRNA7LMNAESR1NR3C2KMT2A | |
| SCHEMBL7549213 | 0.78 | L3MBTL1 (0.41) | MAPK14MAPK13MAPK12MAPK11LMNA | |
| SCHEMBL7548942 | 0.78 | KEAP1 (0.39) | MAPK14MAPK13MAPK12MAPK11KEAP1 | |
| SCHEMBL7553486 | 0.77 | ALDH1A1 (0.37) | LMNAESR1HCRTR1HCRTR2NOS3 | |
| SCHEMBL9060466 | 0.76 | NOS3 (0.40) | MAPK14MAPK13MAPK12MAPK11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997049708-A9 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | — | 1998-05-22 | — | — | WO | disclosed |
| EP-0804438-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | American Cyanamid Company (US) | 1997-11-05 | — | — | EP | disclosed |