Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ASPH | Q12797 | 1/20 | 0.38 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7550390 | 0.90 | KEAP1 (0.42) | KEAP1TP53MAPK14KDM4EASPH | |
| SCHEMBL7547613 | 0.85 | PYGL (0.42) | KEAP1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7554905 | 0.84 | L3MBTL1 (0.41) | KDM4EGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL7553546 | 0.82 | KEAP1 (0.42) | KEAP1TP53MAPK14KDM4EASPH | |
| SCHEMBL7553608 | 0.81 | NAPRT (0.46) | MAPK14MAPK13MAPK12MAPK11NAPRT | |
| SCHEMBL9059196 | 0.81 | TP53 (0.38) | KEAP1TP53MAPTMAPK14MAPK13 | |
| SCHEMBL7550244 | 0.78 | MAPK14 (0.35) | KEAP1TP53MAPK14MAPK13MAPK12 | |
| SCHEMBL7551790 | 0.78 | SGMS2 (0.36) | KEAP1TP53MAPTKDM4EASPH | |
| SCHEMBL7547161 | 0.76 | NAPRT (0.42) | KDM4EASPHKDM8NAPRTDHODH | |
| SCHEMBL7548264 | 0.76 | KMO (0.43) | MAPK14MAPK13MAPK12KDM4EASPH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997049708-A9 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | — | 1998-05-22 | — | — | WO | disclosed |