Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 5/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.37 |
| ▸ | TRPC7 | Q9HCX4 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7562291 | 0.79 | ESR1 (0.36) | SIGMAR1ESR1ESR2ALDH1A1GAA | |
| SCHEMBL6042429 | 0.77 | REN (0.36) | ESR1ESR2TACR1 | |
| SCHEMBL7566408 | 0.67 | DRD4 (0.42) | FAAHMCHR1CHRM4CCR1ALDH1A1 | |
| SCHEMBL7562673 | 0.66 | FAAH (0.46) | FAAHMCHR1CCR1ALDH1A1GAA | |
| SCHEMBL7745919 | 0.65 | FAAH (0.55) | FAAHNAMPTCCR1ALDH1A1GAA | |
| SCHEMBL27279895 | 0.65 | TLR8 (0.45) | ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL6042262 | 0.64 | FAAH (0.43) | FAAHMCHR1CHRM4TRPC3TRPC7 | |
| SCHEMBL16492726 | 0.64 | NAMPT (0.54) | NAMPTGAAMAPTSMN1; SMN2 | |
| SCHEMBL8922008 | 0.63 | CHRM4 (0.59) | CHRM4ALDH1A1GAAMAPTRAB9A | |
| SCHEMBL6042950 | 0.62 | CCR1 (0.44) | FAAHMCHR1CHRM4CCR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002076440-A2 | METHODS OF TREATING ALZHEIMER'S DISEASE WITH PIPERIDIN DERIVATES | ELAN PHARMACEUTICALS, INC. (US) | 2002-10-03 | — | — | WO | disclosed |