Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11357429 | 0.86 | NOS1 (0.33) | HRH1KCNH2NOS1FDPS | |
| SCHEMBL15158965 | 0.84 | NOS1 (0.35) | HRH1KCNH2NOS1MEN1KMT2A | |
| SCHEMBL1198222 | 0.82 | NOS1 (0.35) | HRH1KCNH2NOS1MEN1KMT2A | |
| SCHEMBL22547403 | 0.82 | NOS1 (0.33) | NOS1FDPS | |
| SCHEMBL31010232 | 0.81 | HRH1 (0.32) | HRH1KCNH2NOS1 | |
| SCHEMBL26854965 | 0.79 | HRH1 (0.32) | HRH1KCNH2NOS1 | |
| SCHEMBL31010314 | 0.79 | HRH1 (0.32) | HRH1KCNH2NOS1 | |
| SCHEMBL26854577 | 0.79 | HRH1 (0.32) | HRH1KCNH2NOS1 | |
| SCHEMBL24662260 | 0.78 | — | — | |
| SCHEMBL3347850 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170362211-A1 | SMALL MOLECULE INHIBITORS OF FIBROSIS | THE SCRIPPS RESEARCH INSTITUTE | 2017-12-21 | — | — | US | disclosed |
| US-8729071-B2 | Iminothiadiazine dioxide compounds as BACE inhibitors, compositions and their use | MERCK SHARP & DOHME CORP. (US) | 2014-05-20 | — | — | US | disclosed |
| US-8501786-B2 | Hydroxymethyl pyrrolidines as beta 3 adrenergic receptor agonists | MERCK SHARP & DOHME CORP. (US) | 2013-08-06 | — | — | US | disclosed |
| US-20110034434-A1 | PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2011-02-10 | — | — | US | disclosed |
| US-20110034434-A1 | PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2011-02-10 | — | — | US | disclosed |
| US-20110028461-A1 | HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS | MERCK SHARP & DOHME LLC | 2011-02-03 | — | — | US | disclosed |
| US-20100120740-A1 | PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2010-05-13 | — | — | US | disclosed |
| EP-0807625-B1 | 4-(n,n-Dialkylamino)Aniline compounds, photographic processing composition containing the same and color image-forming method | FUJI PHOTO FILM CO LTD (JP) | 2002-08-21 | — | — | EP | disclosed |
| US-6169206-B1 | 4-(N,N-DIALKYLAMINO)ANILINE COMPOUNDS USEFUL AS DEVELOPING AGENTS FOR SILVER HALIDE COLOR PHOTOGRAPHY OR AS DYES OR INTERMEDIATES | FUJI PHOTO FILM CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| US-6043006-A | 4-(N,N-dialkylamino)aniline compound, photographic processing composition containing the same and color image-forming method | FUJI PHOTO FILM CO., LTD. (JP) | 2000-03-28 | — | — | US | disclosed |
| US-5994546-A | 4-(N,N-DIALKYLAMINO)ANILINE COMPOUNDS HAVING A 4-N SUBSTITUENT WHICH IS A POLYETHYLENEOXY GROUP AND WHICH FORMS A CONDENSED RING WITH BENZENE RING | FUJI PHOTO FILM CO., LTD. (JP) | 1999-11-30 | — | — | US | disclosed |
| US-5773203-A | 4-(N,N-dialkylamino)aniline compounds, photographic processing composition containing the same and color image-forming method | FUJI PHOTO FILM CO., LTD. (JP) | 1998-06-30 | — | — | US | disclosed |
| EP-0807625-A1 | 4-(n,n-Dialkylamino)Aniline compounds, photographic processing composition containing the same and color image-forming method | FUJI PHOTO FILM CO., LTD. (JP) | 1997-11-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028461-A1 | HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS | ADRB3, ADRB1, ADRB2 | HRH1 207/4885KCNH2 565/4885NOS1 1088/4885 |
| US-20100120740-A1 | PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | DDO, DAO, AOC1 | HRH1 827/4885KCNH2 2504/4885NOS1 371/4885 |
| US-20110034434-A1 | PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | DDO, DAO, AOC1 | HRH1 827/4885KCNH2 2504/4885NOS1 371/4885 |
| US-20170362211-A1 | SMALL MOLECULE INHIBITORS OF FIBROSIS | MMP1, COL2A1, MMP8 | HRH1 2500/4885KCNH2 4836/4885NOS1 747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.