Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 8/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 4/20 | 0.32 |
| ▸ | CASP8 | Q14790 | 3/20 | 0.32 |
| ▸ | CASP7 | P55210 | 2/20 | 0.32 |
| ▸ | CASP6 | P55212 | 2/20 | 0.32 |
| ▸ | PRPS1 | P60891 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7487986 | 0.88 | CASP1 (0.55) | CASP1CASP3CASP8CASP7CASP6 | |
| SCHEMBL6161964 | 0.78 | CASP1 (0.54) | CASP1MTNR1AMTNR1BALDH1A1MAPT | |
| SCHEMBL6159212 | 0.76 | CASP1 (0.55) | CASP1ALDH1A1POLB | |
| SCHEMBL6158761 | 0.75 | CASP1 (0.38) | CASP1CASP3CASP8CASP7CASP6 | |
| SCHEMBL6160437 | 0.74 | CASP1 (0.52) | CASP1MTNR1AMTNR1BCASP3CASP8 | |
| SCHEMBL6157827 | 0.74 | CASP1 (0.43) | CASP1CASP3CASP8CASP7CASP6 | |
| SCHEMBL6159488 | 0.74 | PRPS1 (0.30) | PRPS1 | |
| SCHEMBL6157985 | 0.73 | CASP3 (0.41) | CASP1CASP3CASP8CASP7CASP6 | |
| SCHEMBL6161919 | 0.72 | CASP1 (0.47) | CASP1 | |
| SCHEMBL6157558 | 0.72 | KMT2A (0.48) | CASP1MTNR1AMTNR1BALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082127-A4 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2002-10-09 | — | — | EP | claimed |
| EP-1082127-A1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 2001-03-14 | — | — | EP | claimed |
| WO-1999056765-A1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1999-11-11 | — | — | WO | claimed |