Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 7/20 | 0.45 |
| ▸ | CTSK | P43235 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | CTSV | O60911 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7566453 | 0.84 | CTSS (0.47) | CTSSCTSKPOLBMAPK1TAS1R3 | |
| SCHEMBL7567407 | 0.84 | CTSS (0.46) | CTSSCTSKPOLBMAPK1PARP1 | |
| SCHEMBL7573613 | 0.84 | TAS1R3 (0.54) | TAS1R3TAS1R1TAS1R2PARP1PTK2 | |
| SCHEMBL7567803 | 0.83 | CTSS (0.46) | CTSSCTSKPOLBMAPK1PARP1 | |
| SCHEMBL7570655 | 0.78 | AOX1 (0.45) | TAS1R3TAS1R1TAS1R2PTK2HDAC1 | |
| SCHEMBL7572166 | 0.78 | AOX1 (0.45) | POLBTAS1R3TAS1R1TAS1R2PTK2 | |
| SCHEMBL7564792 | 0.77 | NPC1 (0.48) | POLBTAS1R3TAS1R1PARP1PTK2 | |
| SCHEMBL27489866 | 0.75 | PARP1 (0.53) | PARP1CYP3A4CD38 | |
| SCHEMBL7570912 | 0.74 | KDM4E (0.49) | HDAC6 | |
| SCHEMBL7567397 | 0.73 | HDAC1 (0.47) | PARP1HDAC4HDAC3HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934278-B1 | BIS(ACRIDINECARBOXAMIDE) AND BIS(PHENAZINECARBOXAMIDE) AS ANTITUMOUR AGENTS | XENOVA LTD (GB) | 2002-09-04 | — | — | EP | claimed |