Water

Water

SCHEMBL7567835

COC(=O)C=O.O

nearest known ligand 0.00

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL132857 0.97
Hydrochloric Acid SCHEMBL28359575 0.93
Methyl Alcohol SCHEMBL5605313 0.93
Glyoxylate SCHEMBL28767969 0.88 HCAR2 (0.55)
Benzene SCHEMBL30573452 0.88 HCAR2 (0.50)
Acetic Acid Methyl Ester SCHEMBL28490425 0.88 ALDH1A1 (0.59)
Chloroform SCHEMBL11206739 0.85 HCAR2 (0.48)
Glycolic Acid SCHEMBL11022333 0.81 HCAR2 (0.43)
SCHEMBL9339577 0.79 TSHR (0.42)
Dimethyl Fumarate SCHEMBL29070198 0.76 NFE2L2 (0.93)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106536475-B Polyglyoxylic acid esters, their preparation and use 西安大略大学 2021-04-30 CN disclosed
US-20170073452-A1 POLYGLYOXYLATES, MANUFACTURE AND USE THEREOF THE UNIVERSITY OF WESTERN ONTARIO (CA) 2017-03-16 US disclosed
WO-2015168809-A1 POLYGLYOXYLATES, MANUFACTURE AND USE THEREOF THE UNIVERSITY OF WESTERN ONTARIO (CA) 2015-11-12 WO disclosed
EP-0976738-B1 Process for the preparation of propylene ureas DAINIPPON INK & CHEMICALS (JP) 2002-12-04 EP disclosed
EP-1218374-A1 PHARMACEUTICALLY ACTIVE SULFONAMIDE DERIVATIVES Applied Research Systems ARS Holding N.V. (AN) 2002-07-03 EP disclosed
US-6348594-B2 HARDENING OF POLYMERS DAINIPPON INK AND CHEMICALS, INC. (JP) 2002-02-19 US disclosed
US-20020004599-A1 PROPYLENE UREAS AND PROCESS FOR THEIR PREPARATION. DAINIPPON INK AND CHEMICALS, INC. (JP) 2002-01-10 US disclosed
WO-2001023378-A1 PHARMACEUTICALLY ACTIVE SULFONAMIDE DERIVATIVES APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) 2001-04-05 WO disclosed
EP-0863131-B1 Acrylic monomers, polymers thereof and crosslinking compositions DAINIPPON INK & CHEMICALS (JP) 2000-05-17 EP disclosed
EP-0976738-A2 Propylene ureas and the process for their preparation DAINIPPON INK AND CHEMICALS, INC. (JP) 2000-02-02 EP disclosed
US-4405637-A CARBAPENICILLIN BEECHAM GROUP LIMITED (GB) 1983-09-20 US disclosed
US-4401595-A 4-Allyl azetidinone intermediate for β-lactam antibacterial agents BEECHAM GROUP LIMITED (GB) 1983-08-30 US disclosed
EP-0000828-B1 SYNTHETIC BETA-LACTAM COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM BEECHAM GROUP PLC (GB) 1983-03-09 EP disclosed
US-4350703-A β-Lactam antibacterial agents BEECHAM GROUP LIMITED (GB) 1982-09-21 US disclosed
EP-0003740-B1 BETA-LACTAM ANTIBIOTICS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM BEECHAM GROUP PLC (GB) 1982-01-27 EP disclosed
US-4293501-A β-Lactam antibiotics, a process for their preparation and their use in pharmaceutical compositions BEECHAM GROUP LIMITED (GB) 1981-10-06 US disclosed
US-4255441-A β-Lactam antibiotics, a process for their prepaeration and their use in pharmaceutical compositions BEECHAM GROUP LIMITED (GB) 1981-03-10 US disclosed
US-4210661-A Synthetic β-lactam compounds, a process for their preparation and compositions containing them BEECHAM GROUP LIMITED (GB) 1980-07-01 US disclosed
EP-0003740-A2 Beta-lactam antibiotics, a process for their preparation and pharmaceutical compositions containing them BEECHAM GROUP PLC (GB) 1979-09-05 EP disclosed
EP-0000828-A1 Synthetic beta-lactam compounds, a process for their preparation and compositions containing them BEECHAM GROUP PLC (GB) 1979-02-21 EP disclosed